Key Insights

Highlights

Success Rate

89% trial completion (above average)

Clinical Risk Assessment

Based on trial outcomes

Low Risk

Score: 17/100

Termination Rate

7.7%

1 terminated out of 13 trials

Success Rate

88.9%

+2.4% vs benchmark

Late-Stage Pipeline

31%

4 trials in Phase 3/4

Results Transparency

50%

4 of 8 completed with results

Key Signals

4 with results89% success

Data Visualizations

Phase Distribution

7Total
P 1 (1)
P 2 (2)
P 3 (3)
P 4 (1)

Trial Status

Completed8
Active Not Recruiting2
Enrolling By Invitation1
Suspended1
Terminated1

Trial Success Rate

88.9%

Benchmark: 86.5%

Based on 8 completed trials

Clinical Trials (13)

Showing 13 of 13 trials
NCT02476916Phase 2CompletedPrimary

A Study of AG-348 in Adult Participants With Pyruvate Kinase (PK) Deficiency

NCT03481738Active Not RecruitingPrimary

Pyruvate Kinase Deficiency Global Longitudinal Registry

NCT06422351Phase 2SuspendedPrimary

Clinical Trial to Evaluate the Efficacy of Gene Therapy for Pyruvate Kinase Deficiency

NCT05777993Phase 4Enrolling By InvitationPrimary

A Study to Provide Continued Access to Mitapivat for Participants Who Previously Completed an Agios-Sponsored Mitapivat Study

NCT04902833Active Not RecruitingPrimary

Acquired Pyruvate Kinase Deficiency In Clonal Myeloid Neoplasms

NCT03853798Phase 3CompletedPrimary

Extension Study of AG-348 in Adult Participants With Pyruvate Kinase Deficiency Previously Enrolled in AG-348-006 or AG348-C-007

NCT04105166Phase 1CompletedPrimary

Gene Therapy for Pyruvate Kinase Deficiency (PKD)

NCT04995315CompletedPrimary

Pyruvate Kinase Deficiency Global Longitudinal Registry Substudy of Protocol AG348-C-008

NCT04964323TerminatedPrimary

Pyruvate Kinase (PK) Deficiency Global Longitudinal Registry: Patient-Reported Outcomes (PRO)

NCT03866590CompletedPrimary

Pyruvate Kinase Deficiency Epidemiological Study (PIECE)

NCT03548220Phase 3CompletedPrimary

A Study to Evaluate Efficacy and Safety of AG-348 in Not Regularly Transfused Adult Participants With Pyruvate Kinase Deficiency (PKD)

NCT03559699Phase 3CompletedPrimary

A Study Evaluating the Efficacy and Safety of AG-348 in Regularly Transfused Adult Participants With Pyruvate Kinase Deficiency (PKD)

NCT02053480CompletedPrimary

Pyruvate Kinase Deficiency Natural History Study

Showing all 13 trials

Research Network

Activity Timeline