Key Insights

Highlights

Success Rate

90% trial completion (above average)

Clinical Risk Assessment

Based on trial outcomes

Low Risk

Score: 17/100

Termination Rate

7.1%

1 terminated out of 14 trials

Success Rate

90.0%

+3.4% vs benchmark

Late-Stage Pipeline

29%

4 trials in Phase 3/4

Results Transparency

44%

4 of 9 completed with results

Key Signals

4 with results90% success

Data Visualizations

Phase Distribution

8Total
P 1 (2)
P 2 (2)
P 3 (3)
P 4 (1)

Trial Status

Completed9
Active Not Recruiting1
Not Yet Recruiting1
Terminated1
Suspended1
Enrolling By Invitation1

Trial Success Rate

90.0%

Benchmark: 86.6%

Based on 9 completed trials

Clinical Trials (14)

Showing 14 of 14 trials
NCT03481738Active Not RecruitingPrimary

Pyruvate Kinase Deficiency Global Longitudinal Registry

NCT05777993Phase 4Enrolling By InvitationPrimary

A Study to Provide Continued Access to Mitapivat for Participants Who Previously Completed an Agios-Sponsored Mitapivat Study

NCT07612345Phase 1Not Yet RecruitingPrimary

High-Dose Vitamin C in G6PDA and Pyruvate Kinase Deficiency: A Safety Study

NCT04902833CompletedPrimary

Acquired Pyruvate Kinase Deficiency In Clonal Myeloid Neoplasms

NCT02476916Phase 2CompletedPrimary

A Study of AG-348 in Adult Participants With Pyruvate Kinase (PK) Deficiency

NCT06422351Phase 2SuspendedPrimary

Clinical Trial to Evaluate the Efficacy of Gene Therapy for Pyruvate Kinase Deficiency

NCT03853798Phase 3CompletedPrimary

Extension Study of AG-348 in Adult Participants With Pyruvate Kinase Deficiency Previously Enrolled in AG-348-006 or AG348-C-007

NCT04105166Phase 1CompletedPrimary

Gene Therapy for Pyruvate Kinase Deficiency (PKD)

NCT04995315CompletedPrimary

Pyruvate Kinase Deficiency Global Longitudinal Registry Substudy of Protocol AG348-C-008

NCT04964323TerminatedPrimary

Pyruvate Kinase (PK) Deficiency Global Longitudinal Registry: Patient-Reported Outcomes (PRO)

NCT03866590CompletedPrimary

Pyruvate Kinase Deficiency Epidemiological Study (PIECE)

NCT03548220Phase 3CompletedPrimary

A Study to Evaluate Efficacy and Safety of AG-348 in Not Regularly Transfused Adult Participants With Pyruvate Kinase Deficiency (PKD)

NCT03559699Phase 3CompletedPrimary

A Study Evaluating the Efficacy and Safety of AG-348 in Regularly Transfused Adult Participants With Pyruvate Kinase Deficiency (PKD)

NCT02053480CompletedPrimary

Pyruvate Kinase Deficiency Natural History Study

Showing all 14 trials

Research Network

Activity Timeline