Key Insights

Highlights

Success Rate

56% trial completion

Clinical Risk Assessment

Based on trial outcomes

High Risk

Score: 100/100

Termination Rate

23.5%

4 terminated out of 17 trials

Success Rate

55.6%

-31.0% vs benchmark

Late-Stage Pipeline

6%

1 trials in Phase 3/4

Results Transparency

20%

1 of 5 completed with results

Key Signals

1 with results56% success

Data Visualizations

Phase Distribution

8Total
P 1 (4)
P 2 (3)
P 3 (1)

Trial Status

Recruiting6
Completed5
Terminated4
Enrolling By Invitation1
Withdrawn1

Trial Success Rate

55.6%

Benchmark: 86.5%

Based on 5 completed trials

Clinical Trials (17)

Showing 17 of 17 trials
NCT02890342Recruiting

Natural History, Physiology, Microbiome and Biochemistry Studies of Propionic Acidemia

NCT05130437Phase 1RecruitingPrimary

A Study to Assess the Long-term Safety and Clinical Activity of mRNA-3927 in Participants Previously Enrolled in the mRNA-3927-P101 Study

NCT05769621RecruitingPrimary

A Retrospective Study to Characterize Participants With Propionic Acidemia

NCT03159026CompletedPrimary

Review of Charts From Amish/Mennonite Variant PA Patients

NCT04159103Phase 1RecruitingPrimary

Open-Label Study of mRNA-3927 in Participants With Propionic Acidemia

NCT05687474Completed

Baby Detect : Genomic Newborn Screening

NCT05040178Recruiting

An Observational Study of Carbaglu® for the Treatment of MMA and PA in Adults and Pediatrics

NCT03655223Enrolling By Invitation

Early Check: Expanded Screening in Newborns

NCT04176523Recruiting

Understanding the Long-Term Management of Organic Acidemia Patients With CARBAGLU®: A Mixed Methods Approach

NCT04732429Phase 2Terminated

Study of HST5040 in Subjects With Propionic or Methylmalonic Acidemia

NCT05438485Terminated

Natural History Study of Patients With Methylmalonic Acidemia and Propionic Acidemia

NCT04836494Phase 1Terminated

A First in Human, Dose Escalation Study to Evaluate the Safety and Tolerability of BBP-671 in Healthy Volunteers and Patients With Propionic Acidemia or Methylmalonic Acidemia

NCT03484767Completed

"The MaP Study": Mapping the Patient Journey in MMA and PA

NCT02426775Phase 3CompletedPrimary

Carglumic Acid in Methylmalonic Acidemia and Propionic Acidemia

NCT01597440Phase 2TerminatedPrimary

Long-term Outcome of N-Carbamylglutamate Treatment in Propionic Acidemia and Methylmalonic Acidemia

NCT00645879Phase 1CompletedPrimary

Anaplerotic Therapy in Propionic Acidemia

NCT01341379Phase 2Withdrawn

Increasing Ureagenesis in Inborn Errors of Metabolism With N-Carbamylglutamate

Showing all 17 trials

Research Network

Activity Timeline