Key Insights

Highlights

Success Rate

86% trial completion

Clinical Risk Assessment

Based on trial outcomes

Moderate Risk

Score: 37/100

Termination Rate

5.0%

1 terminated out of 20 trials

Success Rate

85.7%

-0.8% vs benchmark

Late-Stage Pipeline

10%

2 trials in Phase 3/4

Results Transparency

67%

4 of 6 completed with results

Key Signals

4 with results86% success

Data Visualizations

Phase Distribution

16Total
Not Applicable (1)
P 1 (6)
P 2 (7)
P 3 (2)

Trial Status

Active Not Recruiting6
Completed6
Recruiting4
Not Yet Recruiting3
Terminated1

Trial Success Rate

85.7%

Benchmark: 86.5%

Based on 6 completed trials

Clinical Trials (20)

Showing 20 of 20 trials
NCT03962543Phase 2Active Not RecruitingPrimary

MEK Inhibitor Mirdametinib (PD-0325901) in Patients With Neurofibromatosis Type 1 Associated Plexiform Neurofibromas

NCT00924196Active Not Recruiting

Natural History Study of Patients With Neurofibromatosis Type I

NCT03363217Phase 2Active Not Recruiting

Trametinib for Pediatric Neuro-oncology Patients With Refractory Tumor and Activation of the MAPK/ERK Pathway.

NCT06502171Phase 1Not Yet Recruiting

Study of Cabozantinib With Selumetinib for Plexiform Neurofibromas

NCT06188741Phase 2Recruiting

Selumetinib for the Prevention of Plexiform Neurofibroma Growth in NF Type 1

NCT06104488Phase 1Recruiting

A Study of Avutometinib for People With Solid Tumor Cancers

NCT07407803Phase 3Not Yet RecruitingPrimary

Evaluation of TQ-B3234 Capsules in Patients With Symptomatic, Non-Surgical Type 1 Neurofibromatosis-Associated Plexiform Neurofibromas

NCT06515860Recruiting

Neurofibromatosis Type 1 Tumor Early Detection Study

NCT07024394Phase 1Not Yet Recruiting

Follow-up Study to Evaluate the Safety and Efficacy of FCN-159 in Pediatric Participants With Neurofibromatosis Type 1

NCT03231306Phase 2Completed

Phase II Study of Binimetinib in Children and Adults With NF1 Plexiform Neurofibromas

NCT05913037Phase 3Active Not Recruiting

FCN-159 in Adult Patients With Symptomatic, Inoperable Neurofibromatosis Type 1-Related Plexiform Neurofibromas

NCT04954001Phase 1Active Not Recruiting

Study to Evaluate the Safety, Tolerability, PK Characteristics and Anti-tumor Activity of FCN-159 in Adult and Pediatric Participants With Neurofibromatosis Type 1

NCT06379230Recruiting

A Retrospective Study on Epidemiological Characteristics of Chinese NF1 Patients in Real World (PROMISE)

NCT03326388Phase 1Completed

Intermittent Dosing Of Selumetinib In Childhood NF1 Associated Tumours

NCT01800032Completed

PET/MRI in CNS and Extra-CNS Tumors of Patients With Neurofibromatosis-1 (NF1)

NCT03820778Not ApplicableActive Not Recruiting

Whole Body MRI to Identify Atypical Neurofibromas in Patients With NF1

NCT00727233Phase 1Completed

Sorafenib to Treat Children and Young Adults With Neurofibromatosis Type 1 and Inoperable Plexiform Neurofibromas

NCT00396019Phase 2CompletedPrimary

Study of PEG-Intron for Plexiform Neurofibromas

NCT00326872Phase 2Terminated

AZD2171 in Treating Patients With Neurofibromatosis Type 1 and Plexiform Neurofibroma and/or Neurofibroma Near the Spine

NCT01412892Phase 2Completed

Use of RAD001 as Monotherapy in the Treatment of Neurofibromatosis 1 Related Internal Plexiform Neurofibromas

Showing all 20 trials

Research Network

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