Key Insights

Highlights

Success Rate

70% trial completion

Clinical Risk Assessment

Based on trial outcomes

Moderate Risk

Score: 49/100

Termination Rate

5.9%

3 terminated out of 51 trials

Success Rate

70.0%

-16.5% vs benchmark

Late-Stage Pipeline

4%

2 trials in Phase 3/4

Results Transparency

43%

3 of 7 completed with results

Key Signals

3 with results70% success

Data Visualizations

Phase Distribution

38Total
Not Applicable (8)
Early P 1 (3)
P 1 (4)
P 2 (21)
P 3 (2)

Trial Status

Recruiting19
Active Not Recruiting8
Completed7
Not Yet Recruiting6
Unknown4
Withdrawn3

Trial Success Rate

70.0%

Benchmark: 86.5%

Based on 7 completed trials

Clinical Trials (51)

Showing 20 of 20 trials
NCT07058805Phase 2Recruiting

Compartmentalized Postoperative Radiotherapy in Head and Neck Cancer

NCT04852328Phase 2RecruitingPrimary

Three Schedules of CUE-101 Administered Before Surgery or Definitive Chemoradiation Therapy in HLA-A*0201 Positive Patients With Locally Advanced, HPV16-Positive Oropharyngeal Squamous-Cell Carcinoma

NCT06532279Phase 2Recruiting

Testing the Addition of the Drug BMX-001, a Radioprotector, or a Placebo to the Usual Chemoradiation Therapy for Patients With Head and Neck Cancer

NCT03952585Phase 2Active Not Recruiting

De-intensified Radiation Therapy With Chemotherapy (Cisplatin) or Immunotherapy (Nivolumab) in Treating Patients With Early-Stage, HPV-Positive, Non-Smoking Associated Oropharyngeal Cancer

NCT04564989RecruitingPrimary

Prospective Observational Study to Validate Circulating HPVDNA and Prognostic Genomic Biomarkers in HPV-associated OPSCC

NCT05268614Phase 2RecruitingPrimary

Risk Adapted De-Intensification of Radio-Chemotherapy for Oropharyngeal Squamous Cell Carcinoma

NCT06662058Not ApplicableRecruiting

Remote Audiometry to Monitor for Treatment-Related Hearing Loss in Patients With H&N SCC Receiving Cisplatin and/or Radiation

NCT06356272Recruiting

Oropharynx (OPX) Biomarker Trial

NCT06980038Phase 2Recruiting

Testing Whether Cemiplimab (REGN2810) Plus CDX-1140 Given Prior to Surgery Are Better Than Cemiplimab (REGN2810) Alone in Patients With Stage III-IV Head and Neck Cancer

NCT07497607Phase 2Not Yet RecruitingPrimary

Reduced Elective Nodal and CTV Dose for HPV+ Oropharyngeal Squamous Cell Carcinoma

NCT07241273Not ApplicableNot Yet RecruitingPrimary

SPECT-CT Guided ELEctive Contralateral Neck Treatment in Lateralized Oropharyngeal Cancer

NCT06323460Phase 2Recruiting

Adaptive De-intensified Radiotherapy Using Circulating Tumor DNA in HPV- Associated Oropharyngeal Cancer

NCT03410615Phase 2Active Not RecruitingPrimary

Cisplatin + Radiotherapy vs Durvalumab + Radiotherapy Followed by Durvalumab vs Durvalumab + Radiotherapy Followed by Tremelimumab + Durvalumab in Intermediate-Risk HPV-Positive Oropharyngeal SCC

NCT05539638RecruitingPrimary

The Role of Circulating Tumour DNA in Head and Neck Cancer

NCT07044635Phase 2RecruitingPrimary

Shortened Course of Radiation Therapy After Trans-oral Robotic Surgery in Patients With HPV-Mediated Oropharyngeal Squamous Cell Carcinoma.

NCT07428148Phase 1Not Yet RecruitingPrimary

Lattice-Based Radiotherapy and Chemoimmunotherapy for Oropharyngeal Squamous Cell Carcinoma

NCT07418034Phase 2Not Yet Recruiting

A Single Arm Phase II Trial in p16-positive Oropharynx Cancer of Selective Dose De-escalation of nodAl VolumEs at Minimal Risk and Primary Site Disease (SAVED)

NCT07407205Not ApplicableActive Not RecruitingPrimary

Tumor Mutational Burden, Liquid Biopsy, Angiogenic Factors and DCE-MRI Perfusion in HPV-Negative Oropharyngeal Cancer

NCT03258554Phase 2Completed

Radiation Therapy With Durvalumab or Cetuximab in Treating Patients With Locoregionally Advanced Head and Neck Cancer Who Cannot Take Cisplatin

NCT05522881RecruitingPrimary

The Registry Study of Genetic Alterations of Oropharyngeal Cancer in Taiwan

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