Key Insights

Highlights

Success Rate

57% trial completion

Clinical Risk Assessment

Based on trial outcomes

High Risk

Score: 60/100

Termination Rate

17.6%

3 terminated out of 17 trials

Success Rate

57.1%

-29.4% vs benchmark

Late-Stage Pipeline

6%

1 trials in Phase 3/4

Results Transparency

125%

5 of 4 completed with results

Key Signals

5 with results57% success

Data Visualizations

Phase Distribution

14Total
Not Applicable (1)
Early P 1 (1)
P 1 (6)
P 2 (5)
P 3 (1)

Trial Status

Active Not Recruiting4
Completed4
Recruiting3
Terminated3
Not Yet Recruiting2
Enrolling By Invitation1

Trial Success Rate

57.1%

Benchmark: 86.5%

Based on 4 completed trials

Clinical Trials (17)

Showing 17 of 17 trials
NCT01362803Phase 1Active Not Recruiting

AZD6244 Hydrogen Sulfate for Children With Nervous System Tumors

NCT06159166Phase 1RecruitingPrimary

Mirdametinib Monotherapy in Adults With Neurofibromatosis 1 (NF1) and Cutaneous Neurofibromas (cNF).

NCT06104488Phase 1Recruiting

A Study of Avutometinib for People With Solid Tumor Cancers

NCT07102394Phase 1RecruitingPrimary

Feasibility and Tolerability of IMLYGIC for the Treatment of Cutaneous Neurofibromas in Adults With NF1

NCT05253131Phase 2Not Yet Recruiting

Trial of Selumetinib and Bromodomain Inhibitor With Durvalumab for Sarcomas

NCT05238909Enrolling By Invitation

Developing Biomarkers of Plexiform Tumor Burden in Patients With Neurofibromatosis-Type 1

NCT02964884Phase 2Active Not Recruiting

Interventions for Reading Disabilities in NF1

NCT07024394Phase 1Not Yet Recruiting

Follow-up Study to Evaluate the Safety and Efficacy of FCN-159 in Pediatric Participants With Neurofibromatosis Type 1

NCT04544007Phase 2TerminatedPrimary

A Phase II Trial of Poly-ICLC for Low-Grade Gliomas

NCT05913037Phase 3Active Not Recruiting

FCN-159 in Adult Patients With Symptomatic, Inoperable Neurofibromatosis Type 1-Related Plexiform Neurofibromas

NCT04954001Phase 1Active Not Recruiting

Study to Evaluate the Safety, Tolerability, PK Characteristics and Anti-tumor Activity of FCN-159 in Adult and Pediatric Participants With Neurofibromatosis Type 1

NCT02101736Phase 2CompletedPrimary

Cabozantinib for Plexiform Neurofibromas (PN) in Subjects With NF1 in Children and Adults

NCT02718131Not ApplicableTerminatedPrimary

A Study of INFUSE Bone Graft (BMP-2) in the Treatment of Tibial Pseudarthrosis in Neurofibromatosis Type 1 (NF1)

NCT00006435Completed

Study of Plexiform Neurofibromas in Neurofibromatosis Type 1

NCT00684398Completed

Adaptation and Quality of Life Among Adults With Neurofibromatosis Type I

NCT01402817Phase 2Terminated

Study of Sutent®/Sunitinib (SU11248) in Subjects With NF-1 Plexiform Neurofibromas

NCT01275586Early Phase 1Completed

Study of Tasigna®/Nilotinib (AMN107) in Neurofibromatosis (NF1) Patients With Plexiform Neurofibromas

Showing all 17 trials

Research Network

Activity Timeline