Key Insights

Highlights

Success Rate

56% trial completion

Clinical Risk Assessment

Based on trial outcomes

High Risk

Score: 65/100

Termination Rate

21.1%

4 terminated out of 19 trials

Success Rate

55.6%

-31.0% vs benchmark

Late-Stage Pipeline

16%

3 trials in Phase 3/4

Results Transparency

120%

6 of 5 completed with results

Key Signals

6 with results56% success

Data Visualizations

Phase Distribution

19Total
Not Applicable (2)
P 1 (4)
P 2 (10)
P 3 (3)

Trial Status

Completed5
Terminated4
Recruiting4
Active Not Recruiting3
Unknown2
Withdrawn1

Trial Success Rate

55.6%

Benchmark: 86.5%

Based on 5 completed trials

Clinical Trials (19)

Showing 19 of 19 trials
NCT04534205Phase 2Recruiting

A Clinical Trial Investigating the Safety, Tolerability, and Therapeutic Effects of BNT113 in Combination With Pembrolizumab Versus Pembrolizumab Alone for Patients With a Form of Head and Neck Cancer Positive for Human Papilloma Virus 16 and Expressing the Protein PD-L1

NCT05980000Phase 2Active Not Recruiting

Ramucirumab and Pembrolizumab vs Pembrolizumab Monotherapy in PD-L1 Positive Head and Neck Squamous-Cell Carcinoma

NCT07501650Phase 1Recruiting

Pembrolizumab Plus Ultrasound-Induced Microbubble Cavitation in Head and Neck Cancer

NCT06239220Phase 2Recruiting

PD-L1 t-haNK, NAI IL-15sa and Cetuximab for Recurrent, Metastatic HNSCC

NCT06790966Phase 3Active Not Recruiting

Phase 3 Study of PDS0101 and Pembrolizumab in HPV16+ Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma

NCT05057247Phase 2Completed

Duvelisib Plus Docetaxel In Recurrent/Metastatic HNSCC

NCT04260126Phase 2CompletedPrimary

Study of PDS0101 and Pembrolizumab Combination I/O in Subjects With HPV16 + Recurrent and/or Metastatic HNSCC

NCT05091190Not ApplicableActive Not Recruiting

Immunotherapy Clearance and Phenotype of Circulating Tumor Cells in Lung and Head and Neck Cancers

NCT02358031Phase 3Completed

A Study of Pembrolizumab (MK-3475) for First Line Treatment of Recurrent or Metastatic Squamous Cell Cancer of the Head and Neck (MK-3475-048/KEYNOTE-048)

NCT03991741Phase 1Terminated

Adoptive Cell Transfer of Autologous Tumor Infiltrating Lymphocytes and High-Dose Interleukin 2 in Select Solid Tumors

NCT06869473Phase 2Recruiting

Cetuximab Plus Platinum and Taxane-based Chemotherapy, Followed by Avelumab and Cetuximab, as First-line Treatment for Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma (HNSCC) Patients With a PD-L1 Combined Positive Score (CPS)≥1≤19.

NCT04902027Phase 1Completed

A Study of Mitoxantrone Hydrochloride Liposome Injection in the Treatment of Recurrent/Metastatic Head and Neck Cancers

NCT05259319Phase 1Unknown

Study Evaluating the Safety and the Efficacy of Combination of Atezolizumab, Tiragolumab and and Stereotactic Body Radiation Therapy in Patients With Oligometastatic Multiorgan (IMMUNOs-SBRT)

NCT04969861Phase 2TerminatedPrimary

BEMPEG With Pembrolizumab vs Pembrolizumab Alone in Patients With Metastatic or Recurrent HNSCC (PROPEL-36)

NCT03937141Phase 2TerminatedPrimary

Efficacy and Safety Trial of ADU-S100 and Pembrolizumab in Head and Neck Cancer

NCT03146338Not ApplicableUnknown

Prophylaxis of Magnesium-rich Mineral Water to Prevent Hypomagnesemia Induced by an Anti-EGFR (OPTIMAG)

NCT01620242Phase 2Completed

A Phase II, Open-Label, Multicenter Trial of Cabazitaxel in Patients With Recurrent or Metastatic Head and Neck Cancer After Failure Of Cisplatin, Cetuximab and Taxanes

NCT03323424Phase 2Withdrawn

Phase II Trial Assessing the Efficacy of Immuno-Radiation Abscopal Effect in Patients With Metastatic Cancers

NCT00088907Phase 3Terminated

Phase III Trial Of Docetaxel Versus Docetaxel Plus ZD1839 In Head And Neck Cancer

Showing all 19 trials

Research Network

Activity Timeline