Key Insights

Highlights

Success Rate

81% trial completion

Published Results

93 trials with published results (15%)

Research Maturity

271 completed trials (45% of total)

Clinical Risk Assessment

Based on trial outcomes

High Risk

Score: 62/100

Termination Rate

10.6%

64 terminated out of 605 trials

Success Rate

80.9%

-5.6% vs benchmark

Late-Stage Pipeline

11%

64 trials in Phase 3/4

Results Transparency

34%

93 of 271 completed with results

Key Signals

93 with results81% success64 terminated

Data Visualizations

Phase Distribution

517Total
Not Applicable (36)
Early P 1 (6)
P 1 (130)
P 2 (281)
P 3 (59)
P 4 (5)

Trial Status

Completed271
Unknown114
Recruiting78
Terminated64
Withdrawn33
Active Not Recruiting24

Trial Success Rate

80.9%

Benchmark: 86.5%

Based on 271 completed trials

Clinical Trials (605)

Showing 20 of 20 trials
NCT06653010Early Phase 1Suspended

Universal CAR-T Cells (REVO-UWD-01) for Metastatic Colorectal Cancer

NCT06675513Early Phase 1Suspended

Autologous CAR-T Cells (WD-01) for Metastatic Colorectal Cancer

NCT05487248Not ApplicableActive Not Recruiting

A Study of On-treatment ctDNA Changes in Chemo-refractory Colorectal Cancer Patients

NCT05513742Phase 2CompletedPrimary

A Study of CTX-009 in Adult Patients With Metastatic Colorectal Cancer

NCT07503756Phase 2RecruitingPrimary

JS212 Combination Therapies in Metastatic Colorectal Cancer

NCT06959550Phase 2RecruitingPrimary

Phase II Study of Anti-PD-1/VEGF Bispecific Antibody Ivonescimab in Patients With Previously Treated Metastatic Colorectal Cancer

NCT06149481Phase 1RecruitingPrimary

Phase I/II Study of the Combination Immunotherapy Regimen: SX-682, TriAdeno Vaccine, Retifanlimab and IL-15 Agonist N-803 (STAR15) for Metastatic Colorectal Cancer (mCRC)

NCT05004350Phase 2Completed

A Study Evaluating the Combination of Encorafenib and Cetuximab Versus Irinotecan/Cetuximab or Infusional 5-fluorouracil (5-FU)/Folinic Acid (FA)/Irinotecan (FOLFIRI)/Cetuximab in Chinese Patients With BRAF V600E Mutant Metastatic Colorectal Cancer.

NCT07559760Phase 2RecruitingPrimary

New Second-Line Combo Therapy for MSS Metastatic Colorectal Cancer

NCT07277322Phase 1Not Yet RecruitingPrimary

Neoadjuvant Dupilumab and Toripalimab in MSS CRC Subjects With Resectable Liver Metastases

NCT01174121Phase 2RecruitingPrimary

Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic Cancer

NCT04793958Phase 3Active Not Recruiting

Phase 3 Study of MRTX849 With Cetuximab vs Chemotherapy in Patients With Advanced Colorectal Cancer With KRAS G12C Mutation (KRYSTAL-10)

NCT04929223Phase 1RecruitingPrimary

A Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients With Metastatic Colorectal Cancer (INTRINSIC)

NCT06252649Phase 3RecruitingPrimary

Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb in Treatment-naïve Participants With Metastatic Colorectal Cancer With KRAS p.G12C Mutation

NCT07549412Phase 3Not Yet RecruitingPrimary

A Study of Precemtabart Tocentecan With or Without Bevacizumab Compared to Trifluridine/Tipiracil Plus Bevacizumab in Participants With Previously Treated Metastatic Colorectal Cancer (PROCEADE-CRC-03)

NCT07543744Phase 1RecruitingPrimary

A Comparative Study of Pharmacokinetics, Safety, and Immunogenicity of RPH-030 and Vectibix® in Patients With Metastatic Colorectal Cancer With Wild-type RAS as First-line Therapy in Combination With FOLFIRI

NCT05652894Phase 3RecruitingPrimary

A Study of HX008 Compared to Chemotherapy in the First-Line Treatment of Subjects With MSI-H/dMMR Metastatic Colorectal Cancer

NCT06792695Phase 2RecruitingPrimary

A Study of Novel Study Interventions and Combinations in Participants With Colorectal Cancer

NCT07079631Phase 1RecruitingPrimary

A Clinical Study to Test if an Investigational Treatment Called BNT314 When Used in Combination With Another Investigational Treatment BNT327 and Chemotherapy, is Beneficial and Safe for Patients With Advanced Colorectal Cancer

NCT02872779Not ApplicableCompleted

Correlation Between Circulating Tumour Markers Early Variations and Clinical Response in First Line Treatment of Metastatic Colorectal Cancer

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