Key Insights

Highlights

Success Rate

77% trial completion

Published Results

82 trials with published results (25%)

Research Maturity

136 completed trials (41% of total)

Clinical Risk Assessment

Based on trial outcomes

High Risk

Score: 59/100

Termination Rate

12.3%

41 terminated out of 334 trials

Success Rate

76.8%

-9.7% vs benchmark

Late-Stage Pipeline

8%

27 trials in Phase 3/4

Results Transparency

60%

82 of 136 completed with results

Key Signals

82 with results77% success41 terminated

Data Visualizations

Phase Distribution

306Total
Not Applicable (9)
Early P 1 (8)
P 1 (123)
P 2 (139)
P 3 (26)
P 4 (1)

Trial Status

Completed136
Recruiting66
Terminated41
Active Not Recruiting36
Unknown32
Withdrawn12

Trial Success Rate

76.8%

Benchmark: 86.5%

Based on 136 completed trials

Clinical Trials (334)

Showing 20 of 20 trials
NCT04115631Phase 2Active Not Recruiting

A Comparison of Three Chemotherapy Regimens for the Treatment of Patients With Newly Diagnosed Mantle Cell Lymphoma

NCT05529069Phase 2RecruitingPrimary

Phase II Study of Pirtobrutinib With Venetoclax In Relapsed-Refractory MCL (Mantle Cell Lymphoma) Patients

NCT03267433Phase 3Active Not RecruitingPrimary

Rituximab With or Without Stem Cell Transplant in Treating Patients With Minimal Residual Disease-Negative Mantle Cell Lymphoma in First Complete Remission

NCT05724121Recruiting

Observational Study of Cardiac Arrhythmias During Treatment With BTK Inhibitors or Venetoclax

NCT01231412Phase 3Completed

Graft-Versus-Host Disease Prophylaxis in Treating Patients With Hematologic Malignancies Undergoing Unrelated Donor Peripheral Blood Stem Cell Transplant

NCT03863184Phase 2Active Not RecruitingPrimary

Acalabrutinib-Lenalidomide-Rituximab in Patients With Untreated MCL

NCT05245656Phase 2RecruitingPrimary

A Study Comparing Rituximab/Bendamustin(RB) Alternating With Rituximab/Bendamustin/Cytarabin(RBAC) With RB Therapy in Elderly Patients With Mentle Cell Lymphoma

NCT06742996Phase 3RecruitingPrimary

A Study to Investigate the Efficacy and Safety of Sonrotoclax Plus Zanubrutinib Compared With Placebo Plus Zanubrutinib in Adults With Relapsed/Refractory Mantle Cell Lymphoma (CELESTIAL-RRMCL)

NCT06263491Phase 2RecruitingPrimary

Phase II Study of Pirtobrutinib, Rituximab (PR) in Previously Untreated Low and Intermediate Risk MCL (Mantle Cell Lymphoma) Patients

NCT06839053Phase 2Recruiting

Sonrotoclax, Rituximab, and Zanubrutinib in Treating Participants With Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, and Mantle Cell Lymphoma

NCT03523975Phase 1RecruitingPrimary

Venetoclax, Lenalidomide and Rituximab in Patients With Previously Untreated Mantle Cell Lymphoma

NCT05006716Phase 1Recruiting

A Dose-Escalation and Expansion Study of BGB-16673 in Participants With B-Cell Malignancies

NCT03623373Phase 2CompletedPrimary

Acalabrutinib With Bendamustine / Rituximab Followed by Cytarabine / Rituximab for Untreated Mantle Cell Lymphoma

NCT06252675Phase 2RecruitingPrimary

Glofitamab With Pirtobrutinib for Relapsed or Refractory Mantle Cell Lymphoma

NCT05020678Phase 1Active Not Recruiting

NKX019, Intravenous Allogeneic Chimeric Antigen Receptor Natural Killer Cells (CAR NK), in Adults With B-cell Cancers

NCT05294731Phase 1Recruiting

Treatment of Chinese Participants With B-Cell Malignancies With BGB-16673, a Bruton Tyrosine Kinase-Targeted Protein-Degrader

NCT07453095Phase 2Not Yet RecruitingPrimary

Study With Glofitamab in Patients With MCL and Inadequate Response or Relapse Following CAR T-cell Therapy

NCT06522386Phase 2Active Not RecruitingPrimary

GATE1: A Multicenter Phase II Study of Pirtobrutinib, Rituximab and Venetoclax Combination Therapy for Patients With Previously Untreated Mantle Cell Lymphoma

NCT04189757Phase 2Active Not RecruitingPrimary

Acalabrutinib for the Treatment of Ibrutinib-Intolerant Mantle Cell Lymphoma

NCT04491370Phase 1Recruiting

Autologous Stem Cell Transplant Followed by Polatuzumab Vedotin in Patients With B-cell Non-Hodgkin and Hodgkin Lymphoma

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