Hypophosphatasia
34
6
10
16
Key Insights
Highlights
Success Rate
100% trial completion (above average)
Clinical Risk Assessment
Based on trial outcomes
Low Risk
Score: 27/100
0.0%
0 terminated out of 34 trials
100.0%
+13.5% vs benchmark
18%
6 trials in Phase 3/4
50%
8 of 16 completed with results
Key Signals
Data Visualizations
Phase Distribution
Trial Status
Trial Success Rate
Benchmark: 86.5%
Based on 16 completed trials
Clinical Trials (34)
United States Hypophosphatasia Molecular Research Center
Phase 3 Study of ALXN1850 in Pediatric Participants With HPP Previously Treated With Asfotase Alfa
The Effect of Monoallelic Variants in the ALPL Gene on the Natural Course of Hypophosphatasia in Russia
Phase 3 Study of ALXN1850 Versus Placebo in Adolescent and Adult Participants With HPP Who Have Not Previously Been Treated With Asfotase Alfa
Natural History Study of Patients With Hypophosphatasia (HPP)
Phase 3 Study of ALXN1850 in Treatment-Naïve Pediatric Participants With HPP
A Prospective Sub-Study of the Global Hypophosphatasia Registry
Mitigate Immune-Mediated Loss of Therapeutic Response to Asfotase Alfa (STRENSIQ®) for Hypophosphatasia
Prospective, Longitudinal, Observational Registry of Adult Patients With Hypophosphatasia (REG-HYPO)
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
Early Check: Expanded Screening in Newborns
Pilot Trial of Single Dose Ilofotase Alfa in Hypophosphatasia
Characteristics of Hypophosphatasia in Adult Patients in Rheumatology and Their Value in Developing an Algorithm to HPP-diagnosis - the COHIR Multi-center Study
Study of ALXN1850 in Participants With Hypophosphatasia (HPP)
Patient Reported Outcomes in Adults With Pediatric-onset Hypophosphatasia Treated With Strensiq® (Asfotase Alfa)
Characteristics of Hypophosphatasia in Adult Patients in Rheumatology
Characterisation of Adult-Onset Hypophosphatasia
Safety and Efficacy Study of ENB-0040 in Juvenile Patients With Hypophosphatasia (HPP)
Circulating miRNAs and Bone Microstructure in Adults With Hypophosphatasia
The PORTRAIT Study