Key Insights

Highlights

Success Rate

100% trial completion (above average)

Clinical Risk Assessment

Based on trial outcomes

Low Risk

Score: 27/100

Termination Rate

0.0%

0 terminated out of 34 trials

Success Rate

100.0%

+13.5% vs benchmark

Late-Stage Pipeline

18%

6 trials in Phase 3/4

Results Transparency

50%

8 of 16 completed with results

Key Signals

8 with results100% success

Data Visualizations

Phase Distribution

15Total
P 1 (2)
P 2 (7)
P 3 (3)
P 4 (3)

Trial Status

Completed16
Recruiting6
Active Not Recruiting4
Unknown4
Withdrawn3
Enrolling By Invitation1

Trial Success Rate

100.0%

Benchmark: 86.5%

Based on 16 completed trials

Clinical Trials (34)

Showing 20 of 20 trials
NCT05062629Active Not RecruitingPrimary

United States Hypophosphatasia Molecular Research Center

NCT06079372Phase 3Active Not RecruitingPrimary

Phase 3 Study of ALXN1850 in Pediatric Participants With HPP Previously Treated With Asfotase Alfa

NCT07390240RecruitingPrimary

The Effect of Monoallelic Variants in the ALPL Gene on the Natural Course of Hypophosphatasia in Russia

NCT06079281Phase 3Active Not RecruitingPrimary

Phase 3 Study of ALXN1850 Versus Placebo in Adolescent and Adult Participants With HPP Who Have Not Previously Been Treated With Asfotase Alfa

NCT02237625RecruitingPrimary

Natural History Study of Patients With Hypophosphatasia (HPP)

NCT06079359Phase 3Active Not RecruitingPrimary

Phase 3 Study of ALXN1850 in Treatment-Naïve Pediatric Participants With HPP

NCT05234567RecruitingPrimary

A Prospective Sub-Study of the Global Hypophosphatasia Registry

NCT06015750Phase 4WithdrawnPrimary

Mitigate Immune-Mediated Loss of Therapeutic Response to Asfotase Alfa (STRENSIQ®) for Hypophosphatasia

NCT05596539RecruitingPrimary

Prospective, Longitudinal, Observational Registry of Adult Patients With Hypophosphatasia (REG-HYPO)

NCT01793168Recruiting

Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford

NCT03655223Enrolling By Invitation

Early Check: Expanded Screening in Newborns

NCT05890794Phase 1CompletedPrimary

Pilot Trial of Single Dose Ilofotase Alfa in Hypophosphatasia

NCT06574282RecruitingPrimary

Characteristics of Hypophosphatasia in Adult Patients in Rheumatology and Their Value in Developing an Algorithm to HPP-diagnosis - the COHIR Multi-center Study

NCT04980248Phase 1CompletedPrimary

Study of ALXN1850 in Participants With Hypophosphatasia (HPP)

NCT04195763CompletedPrimary

Patient Reported Outcomes in Adults With Pediatric-onset Hypophosphatasia Treated With Strensiq® (Asfotase Alfa)

NCT06161142UnknownPrimary

Characteristics of Hypophosphatasia in Adult Patients in Rheumatology

NCT02796885CompletedPrimary

Characterisation of Adult-Onset Hypophosphatasia

NCT00894075Phase 2WithdrawnPrimary

Safety and Efficacy Study of ENB-0040 in Juvenile Patients With Hypophosphatasia (HPP)

NCT04018287UnknownPrimary

Circulating miRNAs and Bone Microstructure in Adults With Hypophosphatasia

NCT04222452UnknownPrimary

The PORTRAIT Study

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