Key Insights

Highlights

Success Rate

86% trial completion

Clinical Risk Assessment

Based on trial outcomes

Moderate Risk

Score: 52/100

Termination Rate

10.7%

3 terminated out of 28 trials

Success Rate

85.7%

-0.8% vs benchmark

Late-Stage Pipeline

29%

8 trials in Phase 3/4

Results Transparency

28%

5 of 18 completed with results

Key Signals

5 with results86% success

Data Visualizations

Phase Distribution

21Total
Not Applicable (8)
P 1 (2)
P 2 (3)
P 3 (7)
P 4 (1)

Trial Status

Completed18
Terminated3
Recruiting3
Active Not Recruiting2
Not Yet Recruiting1
Unknown1

Trial Success Rate

85.7%

Benchmark: 86.5%

Based on 18 completed trials

Clinical Trials (28)

Showing 20 of 20 trials
NCT07543731Not Yet Recruiting

A Real-World Study of Long-Term Adherence and Persistence to Inclisiran, Evolocumab, and Alirocumab

NCT06555120Not ApplicableRecruitingPrimary

Screening for Familial Hypercholesterolemia in Children

NCT03110432Completed

Prospective German Very High Cardiovascular Risk Patients Dyslipidemia Treatment Indication Registry

NCT04656028Not ApplicableActive Not RecruitingPrimary

Genetic Testing and Motivational Counseling for FH

NCT03989167Not ApplicableRecruitingPrimary

Clinical Decision Support for Familial Hypercholesterolemia

NCT00092833Phase 3TerminatedPrimary

Investigational Drug in Patients With Hypercholesterolemia or in Patients With Sitosterolemia (0653-026)(COMPLETED)

NCT04073797Not ApplicableRecruiting

PET Imaging of Inflammation and Lipid Lowering Study

NCT04837638Active Not RecruitingPrimary

Diet Quality and Coronary Artery Calcification in Adults With Heterozygous Familial Hypercholesterolemia

NCT06231459Phase 4CompletedPrimary

Expression of Pro- and Anti-inflammatory Cytokines During Anti-PCSK9 in Familial Hypercholesterolemia

NCT04118348Not ApplicableCompleted

Evaluating the Efficacy of Pediatric Lipid Screening Alerts

NCT01375751Phase 2CompletedPrimary

Reduction of Low-Density Lipoprotein Cholesterol (LDL-C) With PCSK9 Inhibition in Heterozygous Familial Hypercholesterolemia Disorder Study

NCT03795038Not ApplicableCompletedPrimary

Comparison of the Plasma Lipoprotein Apheresis Systems DIAMED and MONET vs. the Whole Blood Apheresis System DALI

NCT04722068Not ApplicableCompletedPrimary

Regeneron 1331 Kinetics Sub-Study HoFH

NCT04313270UnknownPrimary

Subclinical Atherosclerosis in Patients With Familial Hypercholesterolemia Treated With Evolocumab®

NCT04526457Not ApplicableCompletedPrimary

Is Family Screening Improved by Genetic Testing of Familial Hypercholesterolemia

NCT03018678CompletedPrimary

Screening Protocol for a Gene Therapy Trial in Subjects With Homozygous Familial Hypercholesterolemia

NCT01524289Phase 3Completed

Study to Assess the Tolerability and Efficacy of Anacetrapib (MK-0859) Co-Administered With Statin in Participants With Heterozygous Familial Hypercholesterolemia (MK-0859-020)

NCT00281008Phase 2CompletedPrimary

Study of ISIS 301012 (Mipomersen) in Heterozygous Familial Hypercholesterolemia Subjects on Lipid Lowering Therapy

NCT00280995Phase 2CompletedPrimary

Dose-escalating Safety Study of ISIS 301012 in Homozygous Familial Hypercholesterolemia Subjects on Lipid Lowering Therapy

NCT00005168Completed

Hyperapo B and Coronary Heart Disease

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