Key Insights

Highlights

Success Rate

86% trial completion

Published Results

28 trials with published results (33%)

Research Maturity

59 completed trials (69% of total)

Clinical Risk Assessment

Based on trial outcomes

Moderate Risk

Score: 39/100

Termination Rate

11.8%

10 terminated out of 85 trials

Success Rate

85.5%

-1.0% vs benchmark

Late-Stage Pipeline

27%

23 trials in Phase 3/4

Results Transparency

47%

28 of 59 completed with results

Key Signals

28 with results86% success

Data Visualizations

Phase Distribution

70Total
Not Applicable (3)
Early P 1 (1)
P 1 (25)
P 2 (18)
P 3 (12)
P 4 (11)

Trial Status

Completed59
Terminated10
Unknown5
Recruiting4
Not Yet Recruiting2
Withdrawn2

Trial Success Rate

85.5%

Benchmark: 86.5%

Based on 59 completed trials

Clinical Trials (85)

Showing 20 of 20 trials
NCT00980538Phase 3Active Not Recruiting

TMC125-TiDP35-C239 - Continued Access to Etravirine (ETR) in Treatment Experienced HIV-1 Infected Participants

NCT07481175Phase 1Not Yet RecruitingPrimary

Inhibiting the Anti-apoptotic Factor, BCL-2, at the Time of ART Initiation to Promote Apoptosis of HIV-infected Cells and Restrict the Seeding of the HIV Reservoir: An Investigator-initiated Randomised, Controlled, Open-label Clinical Trial (The INITIATE Study)

NCT06517693Phase 1RecruitingPrimary

Safety and Pharmacokinetics Study of PGT121.414.LS Alone and in Combination With VRC07-523LS in Infants Exposed to HIV-1

NCT05612178Phase 1Active Not RecruitingPrimary

A Study to Evaluate the Safety and Effects of Repeated Doses of 3BNC117-LS and 10-1074-LS on Persistent Viral Reservoirs in People Living With HIV and on Suppressive Antiretroviral Therapy

NCT06680479Phase 1SuspendedPrimary

Safety and Immunogenicity of Stabilized CH505 TF chTrimer Vaccination in Adults Living With HIV-1 on Suppressive Antiretroviral Therapy

NCT06252402Early Phase 1RecruitingPrimary

CMV-specific HIV-CAR T Cells as Immunotherapy for HIV/AIDS

NCT06967753Phase 4Recruiting

Switch to Dolutegravir Plus Lamivudine Dual-Therapy in Transgender Women Living With HIV on Virologically Suppressive Antiretroviral Therapy (TRANS-SWITCH)

NCT07122557Not Yet RecruitingPrimary

Real World Effectiveness of Bictegravir/Emtricitabine/Tenofovir Alafenamide(BIC/FTC/TAF) in PLWH in Precarity Settings in France -IMEA073

NCT02285114Phase 2CompletedPrimary

Study To Evaluate Emtricitabine/Tenofovir Alafenamide (F/TAF) in Human Immunodeficiency Virus 1 (HIV-1) Infected Children and Adolescents Virologically Suppressed on a 2-Nucleoside/Nucleotide Reverse Transcriptase Inhibitor (2-NRTI)-Containing Regimen

NCT04442737Phase 4CompletedPrimary

A Study of Darunavir/Cobicistat/Emtricitabine/Tenofovir Alafenamide (D/C/F/TAF) Evaluated as a Fixed Dose Combination Regimen in Participants Switching From an Integrase Inhibitor Who Have Experienced Rapid Weight Gain

NCT06458504RecruitingPrimary

Viral Infection of HSPC Impacts Hematopoiesis

NCT02652260Phase 2CompletedPrimary

Effects of Switching From ATRIPLA™ (Efavirenz, Tenofovir, Emtricitabine) to MK-1439A (Doravirine, Tenofovir, Lamivudine) in Virologically-Suppressed Participants (MK-1439A-028)

NCT03227861Phase 3CompletedPrimary

A Study to Evaluate the Efficacy and Safety of (D/C/F/TAF) Once Daily Fixed Dose Combination (FDC) Regimen in Newly Diagnosed, Antiretroviral Treatment-naive Human Immunodeficiency Virus Type 1 (HIV-1) Infected Participants Receiving Care in a Test and Treat Model of Care

NCT02840474Phase 1CompletedPrimary

Phase 1, Open-label, Single Dose Study to Examine Safety, Tolerability, Pharmacokinetics and Virologic Impact of VRC01LS or VRC07-523LS in HIV-infected Viremic Adults

NCT04956861Not ApplicableCompletedPrimary

HIV-1, Insufficient Sleep and Vascular Endothelial Dysfunction

NCT02275780Phase 3CompletedPrimary

Safety and Efficacy of Doravirine (MK-1439) in Participants With Human Immunodeficiency Virus 1 (HIV-1) (MK-1439-018)

NCT00799864Phase 2CompletedPrimary

A Study to Evaluate the Pharmacokinetics, Safety, Tolerability, and Antiviral Activity of Rilpivirine (TMC278) in Human Immunodeficiency Virus Infected Adolescents and Children Aged Greater Than or Equal to 6 Years

NCT05944848Phase 1CompletedPrimary

A Study of CL-197 Capsules in Healthy Participants

NCT03060629Phase 2TerminatedPrimary

A Study to Assess the Efficacy of a Heterologous Prime/Boost Vaccine Regimen of Ad26.Mos4.HIV and Aluminum Phosphate-Adjuvanted Clade C gp140 in Preventing Human Immunodeficiency Virus (HIV) -1 Infection in Women in Sub-Saharan Africa

NCT05700734Phase 1WithdrawnPrimary

MK-8510 Monotherapy for the Treatment of Anti-retroviral naïve Human Immunodeficiency Virus Type 1 (HIV-1) Infected Participants (MK-8510-002)

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