Key Insights

Highlights

Success Rate

76% trial completion

Published Results

57 trials with published results (47%)

Research Maturity

74 completed trials (61% of total)

Clinical Risk Assessment

Based on trial outcomes

Moderate Risk

Score: 47/100

Termination Rate

19.7%

24 terminated out of 122 trials

Success Rate

75.5%

-11.0% vs benchmark

Late-Stage Pipeline

3%

4 trials in Phase 3/4

Results Transparency

77%

57 of 74 completed with results

Key Signals

57 with results76% success24 terminated

Data Visualizations

Phase Distribution

120Total
Not Applicable (3)
Early P 1 (4)
P 1 (56)
P 2 (53)
P 3 (4)

Trial Status

Completed74
Terminated24
Active Not Recruiting9
Recruiting6
Withdrawn4
Unknown4

Trial Success Rate

75.5%

Benchmark: 86.5%

Based on 74 completed trials

Clinical Trials (122)

Showing 20 of 20 trials
NCT02152982Phase 2Active Not Recruiting

Temozolomide With or Without Veliparib in Treating Patients With Newly Diagnosed Glioblastoma Multiforme

NCT04555577Phase 1Active Not Recruiting

Phase I Trial of DNA-PK Inhibitor (PEPOSERTIB ) in Combination With Radiation and Adjuvant Temozolomide in Newly Diagnosed MGMT Unmethylated and Recurrent Glioblastoma

NCT07089641Phase 1Recruiting

ERAS-801 for the Treatment of Resectable and Progressive or Recurrent or Elderly Newly Diagnosed IDH Wildtype Grade IV Glioblastoma or Gliosarcoma With an EGFR Amplification or Mutation, ERAS801-SARG Trial

NCT03115333Not ApplicableActive Not RecruitingPrimary

DSC-MRI in Measuring rCBV for Early Response to Bevacizumab in Patients With Recurrent Glioblastoma

NCT05095376Phase 3Active Not Recruiting

Testing the Addition of the Chemotherapy Drug Lomustine (Gleostine) to the Usual Treatment (Temozolomide and Radiation Therapy) for Newly Diagnosed MGMT Methylated Glioblastoma

NCT06934889Phase 1Recruiting

Study of ABBV-637 or ABBV-155 With ERAS-801 for People With Glioblastoma

NCT06806228Phase 1Suspended

Phase I Pilot Study to Evaluate the Anti-glioblastoma Effect of S-Gboxin in Standard Treatment of Glioblastoma/Diffuse Midline Glioma and Response to Treatment (Regardless of Mutation Status)

NCT05864534Phase 2Recruiting

Phase 2a Immune Modulation With Ultrasound for Newly Diagnosed Glioblastoma

NCT05091866Early Phase 1TerminatedPrimary

Natural Progesterone for the Treatment of Recurrent Glioblastoma

NCT04396860Phase 2CompletedPrimary

Testing the Use of the Immunotherapy Drugs Ipilimumab and Nivolumab Plus Radiation Therapy Compared to the Usual Treatment (Temozolomide and Radiation Therapy) for Newly Diagnosed MGMT Unmethylated Glioblastoma

NCT04817254Phase 2Completed

Association of Peripheral Blood Immunologic Response to Therapeutic Response to Adjuvant Treatment With Immune Checkpoint Inhibition (ICI) in Patients With Newly Diagnosed Glioblastoma or Gliosarcoma

NCT05698524Phase 1Recruiting

A Study of Temodar With Abexinostat (PCI-24781) for Patients With Recurrent Glioma

NCT04528680Phase 1Active Not Recruiting

Ultrasound-based Blood-brain Barrier Opening and Albumin-bound Paclitaxel and Carboplatin for Recurrent Glioblastoma

NCT02455557Phase 2Active Not Recruiting

SurVaxM Vaccine Therapy and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma

NCT03197506Phase 2Active Not Recruiting

Pembrolizumab and Standard Therapy in Treating Patients With Glioblastoma

NCT02942264Phase 1Terminated

Zotiraciclib (TG02) Plus Dose-Dense or Metronomic Temozolomide Followed by Randomized Phase II Trial of Zotiraciclib (TG02) Plus Temozolomide Versus Temozolomide Alone in Adults With Recurrent Anaplastic Astrocytoma and Glioblastoma

NCT05756985Recruiting

Improving Understanding of Glioblastoma Through Preservation of Biologically Active Brain Tissue

NCT04216329Phase 1Active Not RecruitingPrimary

Selinexor (KPT-330) in Combination With Temozolomide and Radiation Therapy in Patients With Newly Diagnosed Glioblastoma

NCT05084430Phase 1Recruiting

Study of Pembrolizumab and M032 (NSC 733972)

NCT02709226Phase 1Completed

Dose Escalation Trial of Re-irradiation in Good Prognosis Recurrent Glioblastoma

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