Key Insights

Highlights

Success Rate

42% trial completion

Clinical Risk Assessment

Based on trial outcomes

High Risk

Score: 72/100

Termination Rate

18.9%

7 terminated out of 37 trials

Success Rate

41.7%

-44.9% vs benchmark

Late-Stage Pipeline

8%

3 trials in Phase 3/4

Results Transparency

40%

2 of 5 completed with results

Key Signals

2 with results42% success

Data Visualizations

Phase Distribution

32Total
Not Applicable (4)
P 1 (5)
P 2 (20)
P 3 (2)
P 4 (1)

Trial Status

Unknown10
Recruiting8
Terminated7
Completed5
Not Yet Recruiting5
Enrolling By Invitation1

Trial Success Rate

41.7%

Benchmark: 86.5%

Based on 5 completed trials

Clinical Trials (37)

Showing 20 of 20 trials
NCT05258279Phase 2Completed

Lenvatinib in Combination With Carboplatin Pemetrexed and Pembrolizumab for NSCLC With EGFR Mutations

NCT07699952Phase 2Not Yet Recruiting

First-line Therapy With EGFR-TKI Combined With Trastuzumab Rezetecan for Advanced NSCLC Harboring EGFR Mutations Concomitant With HER2 Alterations

NCT07685197Phase 2Not Yet Recruiting

Comparative ¹⁸F-FDG and ⁶⁸Ga-MY6349 PET/CT Imaging for Assessing TROP2 ADC Therapeutic Efficacy in EGFR-TKI Resistant Advanced NSCLC

NCT07637448Phase 2Recruiting

EGFR-TKIs Plus PD-1 in EGFR-Mutant Advanced NSCLC

NCT06685718Phase 1Terminated

A Study Investigating BG-60366 in Adults With Epidermal Growth Factor Receptor (EGFR)-Mutant Non-Small Cell Lung Cancer

NCT07348965Not ApplicableRecruiting

Pulsatile High-dose Furmonertinib in EGFR-mutant NSCLC With Leptomeningeal Metastasis

NCT07287904Not Yet Recruiting

Prediction of Targeted Therapy Efficacy in EGFR-mutant Lung Cancer Patients Using AI-based Multimodal Data

NCT07182708Phase 2Not Yet Recruiting

High-Dose Firmonertinib Plus Bevacizumab as Neoadjuvant Therapy for Resectable EGFRm Stage II-IIIB NSCLC

NCT05257967Not ApplicableRecruitingPrimary

CSF Analysis in EGFR Mutant Non-Small Cell Lung Cancer with Leptomeningeal Disease

NCT04862780Phase 1Terminated

(SYMPHONY) Phase 1/2 Study Targeting EGFR Resistance Mechanisms in NSCLC

NCT05241873Phase 1Terminated

(Concerto) Study of BLU-451 in Advanced Cancers With EGFR Exon 20 Insertion Mutations

NCT04233021Phase 2Completed

Study of Osimertinib in Patients with a Lung Cancer with Brain or Leptomeningeal Metastases with EGFR Mutation

NCT05146219Phase 2Completed

Study of TY-9591 in Patients With a Lung Cancer With Brain or Leptomeningeal Metastases With EGFR Mutation

NCT06730477Enrolling By Invitation

Plasma Exosomes Reveal the Efficacy of Targeted Therapy in Patients With EGFR Mutation in Lung Adenocarcinoma

NCT05948813Phase 2Recruiting

TY-9591 in the Patients With EGFR Mutations in Advanced NSCLC With Brain Metastases

NCT04764214Phase 2Completed

SRT for Residual Oligometastases of NSCLC After 3rd Generation EGFR-TKIs

NCT05244213Phase 2Active Not Recruiting

Neoadjuvant Immunotherapy in EGFR-mutant Localized NSCLC

NCT02949843Phase 2TerminatedPrimary

Targeted Therapy in Treating Patients With Incurable Non-Small Cell Lung Cancer With Genetic Mutations

NCT06363734Phase 2Recruiting

Osimertinib Plus Dalpiciclib in Patients With EGFR-mutant, CDK4/6 Pathway Aberrant, Advanced Non-small Cell Lung Cancer Following Acquired Resistance to Third-generation EGFR TKI: a Phase II Trial

NCT06053099Not ApplicableRecruiting

A Prospective Cohort Study to Evaluate Molecular pRognostic Factors and Resistance Mechanisms to Osimertinib in Adjuvant Treatment of Completely Resected pIB-IIIA Non-small Cell Lung Carcinoma With Common EGFR Mutations (L858R and Del19)

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