Diffuse Intrinsic Pontine Glioma
82
24
33
24
Key Insights
Highlights
Success Rate
69% trial completion
Published Results
12 trials with published results (15%)
Clinical Risk Assessment
Based on trial outcomes
High Risk
Score: 59/100
13.4%
11 terminated out of 82 trials
68.6%
-18.0% vs benchmark
4%
3 trials in Phase 3/4
50%
12 of 24 completed with results
Key Signals
Data Visualizations
Phase Distribution
Trial Status
Trial Success Rate
Benchmark: 86.6%
Based on 24 completed trials
Clinical Trials (82)
Biological Medicine for Diffuse Intrinsic Pontine Glioma (DIPG) Eradication 2.0
Eflornithine (DFMO) and AMXT 1501 for Neuroblastoma, CNS Tumors, and Sarcomas
A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas
Exploratory Study of Effects of Radiation Therapy in Pediatric Patients With Central Nervous System Tumors
Illuminate: A Clinical Study Evaluating CAR T Immune Cell Therapy (BCB-276) for Patients With Diffuse Intrinsic Pontine Glioma (DIPG).
Atovaquone Combined With Radiation in Children With Malignant Brain Tumors
C7R-GD2.CAR T Cells for Patients With GD2-expressing Brain Tumors (GAIL-B)
Study of Tovorafenib in High-Grade Glioma and Diffuse Intrinsic Pontine Glioma (DIPG)
PEACH TRIAL- Precision Medicine and Adoptive Cellular Therapy
IL-8 Receptor-modified CD70 CAR T Cell Therapy in CD70+ Newly Diagnosed and Recurrent Pediatric High-grade Glioma (pHGG) and Newly Diagnosed Diffuse Intrinsic Pontine Glioma (ndDIPG)
Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion
Combination Therapy for the Treatment of Diffuse Midline Gliomas
Study of Relatlimab and Nivolumab (Opdualag) in Replication Repair Deficient HGG and DIPG
Study of Olutasidenib and Temozolomide in HGG
Targeted Pediatric High-Grade Glioma Therapy
Adjuvant Dendritic Cell Immunotherapy for Pediatric Patients With High-grade Glioma or Diffuse Intrinsic Pontine Glioma
A Pilot Study of SurVaxM in Children Progressive or Relapsed Medulloblastoma, High Grade Glioma, Ependymoma and Newly Diagnosed Diffuse Intrinsic Pontine Glioma
Optune for Children With High-Grade Glioma or Ependymoma, and Optune With Radiation Therapy for Children With DIPG
Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant
A Study of VRT106 in Combination With Radiotherapy in Adult Patients With Diffuse Midline Glioma / Diffuse Intrinsic Pontine Glioma