Key Insights

Highlights

Success Rate

43% trial completion

Published Results

12 trials with published results (21%)

Clinical Risk Assessment

Based on trial outcomes

High Risk

Score: 75/100

Termination Rate

21.1%

12 terminated out of 57 trials

Success Rate

42.9%

-43.7% vs benchmark

Late-Stage Pipeline

4%

2 trials in Phase 3/4

Results Transparency

133%

12 of 9 completed with results

Key Signals

12 with results43% success12 terminated

Data Visualizations

Phase Distribution

54Total
Not Applicable (2)
Early P 1 (2)
P 1 (29)
P 2 (19)
P 3 (2)

Trial Status

Active Not Recruiting17
Recruiting13
Terminated12
Completed9
Not Yet Recruiting2
Suspended2

Trial Success Rate

42.9%

Benchmark: 86.5%

Based on 9 completed trials

Clinical Trials (57)

Showing 20 of 20 trials
NCT05896839Phase 1Recruiting

Immunotherapy in Combination With Prednisone and Sirolimus for Kidney Transplant Recipients With Unresectable or Metastatic Skin Cancer

NCT02506153Phase 3Active Not Recruiting

Physician/Patient Choice of Either High-Dose Recombinant Interferon Alfa-2B or Ipilimumab, Versus Pembrolizumab in Treating Patients With Stage III-IV High Risk Melanoma That Has Been Removed by Surgery

NCT03816332Phase 1Active Not Recruiting

Tacrolimus, Nivolumab, and Ipilimumab in Treating Kidney Transplant Recipients With Selected Unresectable or Metastatic Cancers

NCT02224781Phase 3Active Not Recruiting

Dabrafenib and Trametinib Followed by Ipilimumab and Nivolumab or Ipilimumab and Nivolumab Followed by Dabrafenib and Trametinib in Treating Patients With Stage III-IV BRAFV600 Melanoma

NCT05136196Phase 2Recruiting

BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study

NCT05098210Phase 1Recruiting

Personalized Neo-Antigen Peptide Vaccine for the Treatment of Stage IIIC-IV Melanoma, Hormone Receptor Positive HER2 Negative Metastatic Refractory Breast Cancer or Stage III-IV Non-Small Cell Lung Cancer

NCT02298959Phase 1Active Not RecruitingPrimary

Testing the PD-1 Antibody, MK3475, Given With Ziv-aflibercept in Patients With Advanced Cancer

NCT04462406Phase 2Active Not Recruiting

Using Biomarkers to Help Guide Safe Immunotherapy Discontinuation in Patients With Unresectable Stage IIIB-IV Melanoma, The PET-Stop Trial

NCT03819296Phase 1Recruiting

Role of Gut Microbiome and Fecal Transplant on Medication-Induced GI Complications in Patients With Cancer

NCT04697576Phase 1Recruiting

Intralesional Influenza Vaccine for the Treatment of Stage I-IV Melanoma

NCT02650986Phase 1Active Not Recruiting

Gene-Modified T Cells With or Without Decitabine in Treating Patients With Advanced Malignancies Expressing NY-ESO-1

NCT04527549Phase 2TerminatedPrimary

Testing Dabrafenib and Trametinib With or Without Hydroxychloroquine in Stage IIIC or IV BRAF V600E/K Melanoma

NCT03698019Phase 2Active Not Recruiting

A Study to Compare the Administration of Pembrolizumab After Surgery Versus Administration Both Before and After Surgery for High-Risk Melanoma

NCT05967533Phase 1Suspended

The Immune Effects of Fermented Wheat Germ Nutritional Supplementation in Patients With Advanced Solid Tumor Cancers Being Treated With Standard of Care Checkpoint Inhibitors

NCT03025256Phase 1Active Not Recruiting

Intravenous and Intrathecal Nivolumab in Treating Patients With Leptomeningeal Disease

NCT03175432Phase 2Active Not Recruiting

Bevacizumab and Atezolizumab With or Without Cobimetinib in Treating Patients With Untreated Melanoma Brain Metastases

NCT05269381Phase 1Recruiting

Personalized Neoantigen Peptide-Based Vaccine in Combination With Pembrolizumab for Treatment of Advanced Solid Tumors

NCT06075524Recruiting

Evaluation of Anti-PD-1 Therapy by Monitoring T Cell Responses in Melanoma, Lung and Other Cancer Types

NCT01989585Phase 1Active Not Recruiting

Testing the Addition of Navitoclax to the Combination of Dabrafenib and Trametinib in People Who Have BRAF Mutant Melanoma

NCT05588453Phase 1RecruitingPrimary

Natural Killer Cell Therapy (UD TGFbetai NK Cells) and Temozolomide for the Treatment of Stage IV Melanoma Metastatic to the Brain

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