Key Insights

Highlights

Success Rate

43% trial completion

Published Results

11 trials with published results (20%)

Clinical Risk Assessment

Based on trial outcomes

High Risk

Score: 75/100

Termination Rate

21.8%

12 terminated out of 55 trials

Success Rate

42.9%

-43.6% vs benchmark

Late-Stage Pipeline

4%

2 trials in Phase 3/4

Results Transparency

122%

11 of 9 completed with results

Key Signals

11 with results43% success12 terminated

Data Visualizations

Phase Distribution

52Total
Not Applicable (2)
Early P 1 (2)
P 1 (28)
P 2 (18)
P 3 (2)

Trial Status

Active Not Recruiting16
Recruiting16
Terminated12
Completed9
Unknown1
Withdrawn1

Trial Success Rate

42.9%

Benchmark: 86.5%

Based on 9 completed trials

Clinical Trials (55)

Showing 20 of 20 trials
NCT05136196Phase 2Recruiting

BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study

NCT03025256Phase 1Recruiting

Intravenous and Intrathecal Nivolumab in Treating Patients With Leptomeningeal Disease

NCT04462406Phase 2Active Not Recruiting

Using Biomarkers to Help Guide Safe Immunotherapy Discontinuation in Patients With Unresectable Stage IIIB-IV Melanoma, The PET-Stop Trial

NCT03698019Phase 2Active Not Recruiting

A Study to Compare the Administration of Pembrolizumab After Surgery Versus Administration Both Before and After Surgery for High-Risk Melanoma

NCT02506153Phase 3Active Not Recruiting

Physician/Patient Choice of Either High-Dose Recombinant Interferon Alfa-2B or Ipilimumab, Versus Pembrolizumab in Treating Patients With Stage III-IV High Risk Melanoma That Has Been Removed by Surgery

NCT05896839Phase 1Recruiting

Immunotherapy in Combination With Prednisone and Sirolimus for Kidney Transplant Recipients With Unresectable or Metastatic Skin Cancer

NCT03816332Phase 1Active Not Recruiting

Tacrolimus, Nivolumab, and Ipilimumab in Treating Kidney Transplant Recipients With Selected Unresectable or Metastatic Cancers

NCT04902040Phase 1Terminated

Plinabulin in Combination With Radiation/Immunotherapy in Patients With Select Advanced Cancers After Progression on PD-1 or PD-L1 Targeted Antibodies

NCT06151847Phase 2CompletedPrimary

Lifileucel With Reduced Dose Fludarabine/Cyclophosphamide Lymphodepletion and Interleukin-2 for the Treatment of Patients With Unresectable or Metastatic Melanoma

NCT05764395Phase 2Active Not Recruiting

Rigosertib Plus Pembrolizumab in Treating Patients With Unresectable/Metastatic Melanoma Refractory to PD-1 Inhibitors

NCT05341349Phase 1TerminatedPrimary

Stereotactic Radiosurgery and Immune Checkpoint Inhibitors With NovoTTF-200M for the Treatment of Melanoma Brain Metastases

NCT05026983Phase 2RecruitingPrimary

Binimetinib and Encorafenib for the Treatment of Metastatic Melanoma and Central Nervous System Metastases

NCT05039801Phase 1Recruiting

IACS-6274 With or Without Bevacizumab and Paclitaxel for the Treatment of Advanced Solid Tumors

NCT03175432Phase 2Active Not Recruiting

Bevacizumab and Atezolizumab With or Without Cobimetinib in Treating Patients With Untreated Melanoma Brain Metastases

NCT01989585Phase 1Active Not Recruiting

Testing the Addition of Navitoclax to the Combination of Dabrafenib and Trametinib in People Who Have BRAF Mutant Melanoma

NCT02298959Phase 1Active Not RecruitingPrimary

Testing the PD-1 Antibody, MK3475, Given With Ziv-aflibercept in Patients With Advanced Cancer

NCT04557956Phase 1Active Not RecruitingPrimary

Testing the Addition of the Anti-cancer Drug, Tazemetostat, to the Usual Treatment (Dabrafenib and Trametinib) for Metastatic Melanoma That Has Progressed on the Usual Treatment

NCT04527549Phase 2TerminatedPrimary

Testing Dabrafenib and Trametinib With or Without Hydroxychloroquine in Stage IIIC or IV BRAF V600E/K Melanoma

NCT04514484Phase 1Active Not Recruiting

Testing the Combination of the Anti-cancer Drugs XL184 (Cabozantinib) and Nivolumab in Patients With Advanced Cancer and HIV

NCT06391099Not ApplicableRecruitingPrimary

Ketogenic Dietary Intervention to Improve Response to Immunotherapy in Patients With Metastatic Melanoma and Metastatic Kidney Cancer

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