Key Insights

Highlights

Success Rate

67% trial completion

Published Results

14 trials with published results (27%)

Clinical Risk Assessment

Based on trial outcomes

Moderate Risk

Score: 47/100

Termination Rate

15.7%

8 terminated out of 51 trials

Success Rate

66.7%

-19.9% vs benchmark

Late-Stage Pipeline

10%

5 trials in Phase 3/4

Results Transparency

88%

14 of 16 completed with results

Key Signals

14 with results67% success

Data Visualizations

Phase Distribution

47Total
Not Applicable (6)
Early P 1 (1)
P 1 (15)
P 2 (20)
P 3 (3)
P 4 (2)

Trial Status

Completed16
Recruiting13
Terminated8
Active Not Recruiting6
Not Yet Recruiting3
Unknown3

Trial Success Rate

66.7%

Benchmark: 86.6%

Based on 16 completed trials

Clinical Trials (51)

Showing 20 of 20 trials
NCT07011810Phase 2RecruitingPrimary

Axatilimab for Sclerotic Chronic Graft-versus-Host Disease

NCT07535008Not ApplicableRecruitingPrimary

Dental Cleaning to Prevent Chronic Graft-Versus-Host Disease

NCT01804686Phase 3Recruiting

A Long-term Extension Study of PCI-32765 (Ibrutinib)

NCT07733141Not ApplicableNot Yet RecruitingPrimary

Mindfulness Intervention to Reduce Patient Reported Symptoms in Patients With Chronic Graft-Versus-Host Disease

NCT07726914Phase 1Not Yet RecruitingPrimary

Study to Compare the Plasma Concentration of Belumosudil Given as an Oral Suspension and as a Tablet to Healthy Adult Male Participants

NCT06247150Not ApplicableRecruitingPrimary

Tissue Immune Landscape of Graft Versus Host Disease After Allogeneic Stem Cell Transplantation (TIL-GVHD)

NCT04431479Active Not RecruitingPrimary

Predicting the Quality of Response to Specific Treatments in Patients With cGVHD, PQRST Study

NCT04212416Phase 1Active Not RecruitingPrimary

Leflunomide in Treating Patients With Steroid Dependent Chronic Graft Versus Host Disease

NCT04640025Phase 2Terminated

A Rollover Study to Provide Continued Treatment for Participants Previously Enrolled in Studies of Itacitinib

NCT06663722Phase 2RecruitingPrimary

Axatilimab in Combination With Extracorporeal Photopheresis (ECP) in Chronic Graft-versus-Host Disease

NCT05922761Phase 2Recruiting

BElumosudil for Bronchiolitis Obliterans Prevention/Therapy (BEBOP)

NCT07116031Phase 2RecruitingPrimary

A Study of Belumosudil in Children With Chronic Graft Versus Host Disease (schoolROCK)

NCT05996627Phase 2RecruitingPrimary

Belumosudil for the Pre-emptive Treatment of Patients With Chronic Graft Versus Host Disease

NCT01954979Phase 1CompletedPrimary

Abatacept to Treat Steroid Refractory Chronic Graft Versus Host Disease (cGVHD)

NCT06616415Phase 4CompletedPrimary

A Clinical Study to Evaluate the Pharmacokinetics, Efficacy, and Safety of Belumosudil in Chinese Adolescents With cGVHD Who Have Had an Inadequate Response to Glucocorticoids or Other Systemic Therapies

NCT06271616Phase 2TerminatedPrimary

Ibrutinib for the Prevention of Chronic Graft-Versus-Host Disease in Patients Undergoing Donor Stem Cell Transplant

NCT07135973Phase 4Not Yet RecruitingPrimary

A Study to Investigate Safety of Belumosudil in Participants Aged 12 Years and Above, With Chronic Graft-versus-host Disease (cGVHD)

NCT06046248Phase 2RecruitingPrimary

Belumosudil and Rituximab for Primary Treatment of Chronic Graft-Versus-Host-Disease

NCT00637689Active Not RecruitingPrimary

Improving Outcomes Assessment in Chronic GVHD

NCT06695507Phase 1TerminatedPrimary

Upfront Ruxolitinib for Chronic Graft-vs-host Disease

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Research Network

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