Central Nervous System (CNS) Metastases
5
2
2
2
Key Insights
Highlights
Success Rate
100% trial completion (above average)
Treatment Research
6 treatments under study, led by Zorifertinib
Research Leaders
6 sponsors active, led by Alpha Biopharma (Jiangsu) Co., Ltd.
Related Conditions
Often studied with 4 related conditions
Clinical Risk Assessment
Based on trial outcomes
Moderate Risk
Score: 50/100
0.0%
0 terminated out of 5 trials
100.0%
+13.4% vs benchmark
0%
0 trials in Phase 3/4
0%
0 of 2 completed with results
Key Signals
Data Visualizations
Phase Distribution
Trial Status
Trial Success Rate
Benchmark: 86.6%
Based on 2 completed trials
Clinical Trials (5)
Material Balance of [14C]Zorifertinib in Healthy Adult Male Participants in China
A Phase II Observational Clinical Study on the Relationship Between Cerebrospinal Fluid Drug Concentration and Efficacy of Trastuzumab Deruxtecan in Central Nervous System Metastatic Breast Cancer
A Prospective Cohort Study of Zorifertinib as a First-line Treatment in Patients With Epidermal Growth Factor Receptor-mutant Advanced Non-small Cell Lung Cancer With Central Nervous System (CNS) Metastases
Intermittent High-Dose Lapatinib in Tandem With Capecitabine for HER2 Overexpressed/Amplified Metastatic Breast Cancer With Central Nervous System (CNS) Metastases
Phase II Trial of Chemotherapy With Temodar With Topotecan for CNS Metastasis of Solid Tumors
Research Network
Common Treatments
- Zorifertinib1
- Temozolomide1
- No Interventions1
- Lapatinib In Tandem With Capecitabine1
- 14czorifertinib Oral Formulation1
Active Sponsors
- Alpha Biopharma (Jiangsu) Co., Ltd.2
- The Methodist Hospital Research Institute1
- Memorial Sloan Kettering Cancer Center1
- Queens Cancer Center of Queens Hospital1
- Fudan University1
Top Investigators
Memorial Sloan Kettering Cancer Center
The First Affiliated Hospital of Soochow University
Guangdong Provincial People's Hospital
Methodist Neurological Institute
Related Conditions
- Egfr Mutant Advanced Nonsmall Cell Lung Cancer2
- Breast Cancer1
- Metastatic Breast Cancer1
- Brain Metastases1