Key Insights

Highlights

Success Rate

88% trial completion (above average)

Clinical Risk Assessment

Based on trial outcomes

Low Risk

Score: 17/100

Termination Rate

5.4%

2 terminated out of 37 trials

Success Rate

87.5%

+1.0% vs benchmark

Late-Stage Pipeline

30%

11 trials in Phase 3/4

Results Transparency

43%

6 of 14 completed with results

Key Signals

6 with results88% success

Data Visualizations

Phase Distribution

22Total
Not Applicable (7)
P 1 (1)
P 2 (3)
P 3 (6)
P 4 (5)

Trial Status

Completed14
Withdrawn7
Unknown7
Recruiting4
Terminated2
Enrolling By Invitation1

Trial Success Rate

87.5%

Benchmark: 86.5%

Based on 14 completed trials

Clinical Trials (37)

Showing 20 of 20 trials
NCT04770012Phase 3RecruitingPrimary

AERIAL Trial: Antiplatelet Therapy in Heart Transplantation

NCT06089486Not ApplicableRecruitingPrimary

MARINER Trial: Multiparametric Cardiac PET for CAV Surveillance After Heart Transplantation

NCT03217786Active Not RecruitingPrimary

Early Post Transplant Cardiac Allograft Vasculopathy

NCT05756088WithdrawnPrimary

Determining the Association of Microvascular Disease as Assessed by PET and Graft Injury by Donor Derived Cell Free DNA

NCT07020039Not Yet RecruitingPrimary

Comparing PCCT With ICA and IVUS in Detecting Cardiac Allograft Vasculopathy

NCT06899828Completed

Unraveling Mechanism of Action of Extracorporeal Photopheresis in Heart and Lung Transplant Patients

NCT02798731RecruitingPrimary

Physiologic Assessment of Microvascular Function in Heart Transplant Patients

NCT04226521Not ApplicableCompletedPrimary

Extracorporeal Photopheresis and Early Cardiac Graft Vasculopathy

NCT05826444RecruitingPrimary

Microvascular Cardiac Allograft Vasculopathy Trial

NCT06147271Phase 2Enrolling By Invitation

Impact of SGLT2 Inhibitors in Heart Transplant Recipients

NCT05373108Phase 4CompletedPrimary

Endothelin-1 and Cardiac Allograft Vasculopathy (CAV)

NCT03734211Phase 3CompletedPrimary

Cholesterol Lowering With EVOLocumab to Prevent Cardiac Allograft Vasculopathy in De-novo Heart Transplant Recipients

NCT03386539Phase 3Unknown

Tacrolimus/Everolimus vs. Tacrolimus/MMF in Pediatric Heart Transplant Recipients Using the MATE Score

NCT04193306Phase 4UnknownPrimary

Efficacy and Safety Of Alirocumab to Prevent Early Cardiac Allograft Vasculopathy in Recent Heart Transplant Recipients

NCT02377648Phase 4CompletedPrimary

Safety and Efficacy of Everolimus - Eluting Bioresorbable Vascular Scaffold for Cardiac Allograft Vasculopathy

NCT04791852CompletedPrimary

Potential Role of Donor-derived Cell-Free DNA as a Biomarker in Cardiac Allograft Vasculopathy

NCT02013037Phase 3Completed

The De-novo Use of Eculizumab in Presensitized Patients Receiving Cardiac Transplantation

NCT02082821CompletedPrimary

A P2X7R Single Nucleotide Mutation Promotes Chronic Allograft Vasculopathy

NCT01278745Phase 2TerminatedPrimary

Prevention of Cardiac Allograft Vasculopathy Using Rituximab (Rituxan) Therapy in Cardiac Transplantation

NCT04105803UnknownPrimary

Cardiac Mitochondrial Function After Heart Transplantation

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Research Network

Activity Timeline