Key Insights

Highlights

Success Rate

90% trial completion (above average)

Clinical Risk Assessment

Based on trial outcomes

Moderate Risk

Score: 50/100

Termination Rate

3.4%

2 terminated out of 58 trials

Success Rate

90.0%

+3.4% vs benchmark

Late-Stage Pipeline

3%

2 trials in Phase 3/4

Results Transparency

17%

3 of 18 completed with results

Key Signals

3 with results90% success

Data Visualizations

Phase Distribution

37Total
Not Applicable (17)
P 1 (8)
P 2 (10)
P 3 (1)
P 4 (1)

Trial Status

Completed18
Recruiting13
Active Not Recruiting10
Unknown9
Withdrawn3
Terminated2

Trial Success Rate

90.0%

Benchmark: 86.6%

Based on 18 completed trials

Clinical Trials (58)

Showing 20 of 20 trials
NCT03702309Recruiting

Liquid Biopsy Evaluation and Repository Development at Princess Margaret

NCT05898009Not ApplicableCompleted

Contribution of Oncogenetics in Breast Cancer in Reunion Epidemiology of Breast Cancer in Reunion: Study of the Reunion Mutation on BRCA2

NCT06177171Phase 1Active Not Recruiting

Olaparib and ASTX727 in BRCA1/2- and Homologous Recombination Deficient (HRD)-Mutated Tumors

NCT06488378Phase 1Recruiting

Phase Ib Study of Axatilimab in Combination With Olaparib in BRCA1/2 and PALB2- Associated Metastatic HER2-negative Breast Cancer

NCT05420064Not ApplicableRecruiting

An Intervention to Increase Genetic Testing in Families Who May Share a Gene Mutation Related to Cancer Risk and An Intervention to Help Patients and Their Primary Care Providers Stay Up-to-date About Uncertain Genetic Test Results

NCT06380660Phase 1Active Not Recruiting

Study of ACE-86225106 to Treat Patients With Advanced Solid Tumors

NCT06972719Not ApplicableRecruiting

Hormone Replacement Therapy After Risk Reducing Salpingo-oophorectomy

NCT05498272Phase 2Active Not Recruiting

Study of Neoadjuvant PARP Inhibition Followed by Radical Prostatectomy in Patients With Unfavorable Intermediate-Risk or High-Risk Prostate Cancer With Select HRR Gene Alterations

NCT04499534Active Not Recruiting

BRCA1/2 Flu Vaccine

NCT04613440Not ApplicableActive Not Recruiting

FaCT Trial (Facilitated Cascade Testing Trial)

NCT05694715Phase 1Recruiting

Combination Therapy in Cancers With Mutations in DNA Repair Genes

NCT03351803Active Not Recruiting

BRCA Founder OutReach (BFOR) Study

NCT04428736Completed

Evaluating Cascade Communication Methods

NCT06817694Not ApplicableRecruiting

Cognitive Behavioral Therapy for Fear of Cancer Recurrence in Women With BRCA1/2 Gene

NCT07499999Phase 2Not Yet Recruiting

Randomized Double-Blind Phase II Trial of Baby Exemestane Versus Baby Tamoxifen in Post-Menopausal Women at High Risk for Breast Cancer

NCT06395519Phase 1Recruiting

A Study of PARG Inhibitor ETX-19477 in Patients With Advanced Solid Malignancies

NCT01608074Not ApplicableActive Not Recruiting

Radical Fimbriectomy for Young BRCA Mutation Carriers

NCT04780945Phase 2Terminated

Functional Analysis of BRCAness

NCT04150042Phase 1Recruiting

SHARON: A Clinical Trial for Metastatic Cancer Using Chemotherapy and Patients' Own Stem Cells

NCT03685331Phase 1Completed

HOPE: Olaparib, Palbociclib and Fulvestrant in Patients With BRCA Mutation-associated, HR+, HER2-metastatic Breast Cancer

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