BRCA2 Mutation
58
18
24
17
Key Insights
Highlights
Success Rate
89% trial completion (above average)
Clinical Risk Assessment
Based on trial outcomes
Moderate Risk
Score: 50/100
3.4%
2 terminated out of 58 trials
89.5%
+3.0% vs benchmark
3%
2 trials in Phase 3/4
18%
3 of 17 completed with results
Key Signals
Data Visualizations
Phase Distribution
Trial Status
Trial Success Rate
Benchmark: 86.5%
Based on 17 completed trials
Clinical Trials (58)
BRCA Founder OutReach (BFOR) Study
Olaparib and ASTX727 in BRCA1/2- and Homologous Recombination Deficient (HRD)-Mutated Tumors
Evaluating Cascade Communication Methods
Cognitive Behavioral Therapy for Fear of Cancer Recurrence in Women With BRCA1/2 Gene
Randomized Double-Blind Phase II Trial of Baby Exemestane Versus Baby Tamoxifen in Post-Menopausal Women at High Risk for Breast Cancer
A Study of PARG Inhibitor ETX-19477 in Patients With Advanced Solid Malignancies
Hormone Replacement Therapy After Risk Reducing Salpingo-oophorectomy
Radical Fimbriectomy for Young BRCA Mutation Carriers
Combination Therapy in Cancers With Mutations in DNA Repair Genes
Functional Analysis of BRCAness
SHARON: A Clinical Trial for Metastatic Cancer Using Chemotherapy and Patients' Own Stem Cells
Study of Neoadjuvant PARP Inhibition Followed by Radical Prostatectomy in Patients With Unfavorable Intermediate-Risk or High-Risk Prostate Cancer With Select HRR Gene Alterations
HOPE: Olaparib, Palbociclib and Fulvestrant in Patients With BRCA Mutation-associated, HR+, HER2-metastatic Breast Cancer
Study of ACE-86225106 to Treat Patients With Advanced Solid Tumors
LobularCard Trial: Searching for Novel Germline Mutations in Lobular Breast Cancer Patients
Evaluating the Addition of Elacestrant (Oral SERD) to Olaparib (PARP-inhibitor) in Patients With Advanced/Metastatic HR+/HER2- Breast Cancer
BRCA Mutation Carriers' Platform a Multicenter Study
Liquid Biopsy Evaluation and Repository Development at Princess Margaret
An Intervention to Increase Genetic Testing in Families Who May Share a Gene Mutation Related to Cancer Risk and An Intervention to Help Patients and Their Primary Care Providers Stay Up-to-date About Uncertain Genetic Test Results
Genetic Education in BRCA Families