BRCA1 Mutation
62
16
23
18
Key Insights
Highlights
Success Rate
78% trial completion
Clinical Risk Assessment
Based on trial outcomes
High Risk
Score: 62/100
8.1%
5 terminated out of 62 trials
78.3%
-8.2% vs benchmark
6%
4 trials in Phase 3/4
28%
5 of 18 completed with results
Key Signals
Data Visualizations
Phase Distribution
Trial Status
Trial Success Rate
Benchmark: 86.5%
Based on 18 completed trials
Clinical Trials (62)
Evaluating Cascade Communication Methods
Hormone Replacement Therapy After Risk Reducing Salpingo-oophorectomy
A Study of PARG Inhibitor ETX-19477 in Patients With Advanced Solid Malignancies
Radical Fimbriectomy for Young BRCA Mutation Carriers
Combination Therapy in Cancers With Mutations in DNA Repair Genes
BRCA Founder OutReach (BFOR) Study
Functional Analysis of BRCAness
Olaparib and ASTX727 in BRCA1/2- and Homologous Recombination Deficient (HRD)-Mutated Tumors
SHARON: A Clinical Trial for Metastatic Cancer Using Chemotherapy and Patients' Own Stem Cells
Study of Neoadjuvant PARP Inhibition Followed by Radical Prostatectomy in Patients With Unfavorable Intermediate-Risk or High-Risk Prostate Cancer With Select HRR Gene Alterations
HOPE: Olaparib, Palbociclib and Fulvestrant in Patients With BRCA Mutation-associated, HR+, HER2-metastatic Breast Cancer
Study of ACE-86225106 to Treat Patients With Advanced Solid Tumors
LobularCard Trial: Searching for Novel Germline Mutations in Lobular Breast Cancer Patients
Evaluating the Addition of Elacestrant (Oral SERD) to Olaparib (PARP-inhibitor) in Patients With Advanced/Metastatic HR+/HER2- Breast Cancer
BRCA Mutation Carriers' Platform a Multicenter Study
Liquid Biopsy Evaluation and Repository Development at Princess Margaret
An Intervention to Increase Genetic Testing in Families Who May Share a Gene Mutation Related to Cancer Risk and An Intervention to Help Patients and Their Primary Care Providers Stay Up-to-date About Uncertain Genetic Test Results
Genetic Education in BRCA Families
BRCA1/2 Flu Vaccine
FaCT Trial (Facilitated Cascade Testing Trial)