BRCA1 Mutation
62
16
23
18
Key Insights
Highlights
Success Rate
78% trial completion
Clinical Risk Assessment
Based on trial outcomes
High Risk
Score: 62/100
8.1%
5 terminated out of 62 trials
78.3%
-8.2% vs benchmark
6%
4 trials in Phase 3/4
28%
5 of 18 completed with results
Key Signals
Data Visualizations
Phase Distribution
Trial Status
Trial Success Rate
Benchmark: 86.5%
Based on 18 completed trials
Clinical Trials (62)
BRCA Founder OutReach (BFOR) Study
Olaparib and ASTX727 in BRCA1/2- and Homologous Recombination Deficient (HRD)-Mutated Tumors
Evaluating Cascade Communication Methods
A Study of PARG Inhibitor ETX-19477 in Patients With Advanced Solid Malignancies
Hormone Replacement Therapy After Risk Reducing Salpingo-oophorectomy
Radical Fimbriectomy for Young BRCA Mutation Carriers
Combination Therapy in Cancers With Mutations in DNA Repair Genes
Functional Analysis of BRCAness
SHARON: A Clinical Trial for Metastatic Cancer Using Chemotherapy and Patients' Own Stem Cells
Study of Neoadjuvant PARP Inhibition Followed by Radical Prostatectomy in Patients With Unfavorable Intermediate-Risk or High-Risk Prostate Cancer With Select HRR Gene Alterations
HOPE: Olaparib, Palbociclib and Fulvestrant in Patients With BRCA Mutation-associated, HR+, HER2-metastatic Breast Cancer
Study of ACE-86225106 to Treat Patients With Advanced Solid Tumors
LobularCard Trial: Searching for Novel Germline Mutations in Lobular Breast Cancer Patients
Evaluating the Addition of Elacestrant (Oral SERD) to Olaparib (PARP-inhibitor) in Patients With Advanced/Metastatic HR+/HER2- Breast Cancer
BRCA Mutation Carriers' Platform a Multicenter Study
Liquid Biopsy Evaluation and Repository Development at Princess Margaret
An Intervention to Increase Genetic Testing in Families Who May Share a Gene Mutation Related to Cancer Risk and An Intervention to Help Patients and Their Primary Care Providers Stay Up-to-date About Uncertain Genetic Test Results
Genetic Education in BRCA Families
BRCA1/2 Flu Vaccine
FaCT Trial (Facilitated Cascade Testing Trial)