Key Insights

Highlights

Success Rate

83% trial completion

Clinical Risk Assessment

Based on trial outcomes

High Risk

Score: 72/100

Termination Rate

11.4%

4 terminated out of 35 trials

Success Rate

82.6%

-3.9% vs benchmark

Late-Stage Pipeline

6%

2 trials in Phase 3/4

Results Transparency

26%

5 of 19 completed with results

Key Signals

5 with results83% success

Data Visualizations

Phase Distribution

33Total
Not Applicable (2)
Early P 1 (6)
P 1 (14)
P 2 (9)
P 3 (2)

Trial Status

Completed19
Recruiting5
Terminated4
Not Yet Recruiting3
Active Not Recruiting2
Withdrawn2

Trial Success Rate

82.6%

Benchmark: 86.5%

Based on 19 completed trials

Clinical Trials (35)

Showing 20 of 20 trials
NCT07664176Phase 1Not Yet Recruiting

NgFUS NIVO: NeuroNavigation-Guided Focused Ultrasound With Nivolumab in Relapsed and Progressive DMG and Other High Grade Brain Tumors

NCT04427384RecruitingPrimary

Registry of Patients With Brain Tumors Treated With STaRT (GammaTiles)

NCT02303678Phase 1Completed

D2C7 for Adult Patients With Recurrent Malignant Glioma

NCT06666712Phase 1RecruitingPrimary

Chronic CED of TPT for Recurrent Malignant Glioma

NCT05629702Phase 2Recruiting

ARISTOCRAT: Blinded Trial of Temozolomide +/- Cannabinoids

NCT04988750Not ApplicableCompleted

Evaluate the Safety and Preliminary Efficacy of the Combination of NaviFUS System With Re-irradiation for rGBM Patients

NCT02800486Phase 2Recruiting

Super Selective Intra-arterial Repeated Infusion of Cetuximab (Erbitux) With Reirradiation for Treatment of Relapsed/Refractory GBM, AA, and AOA

NCT06496971Phase 3Recruiting

A Prospective Pivotal Study to Evaluate the Efficacy and Safety of Avastin® Bevacizumab (BEV) With or Without Microbubble-mediated Focused Ultrasound (FUS-MB) Using NaviFUS System in Recurrent Glioblastoma Multiforme Patients

NCT07390539Phase 1Not Yet Recruiting

B7-H3.CD28Z.CART in CNS Neoplasms

NCT06057168Phase 3Completed

Performance of Elucirem in DSC-MRI Perfusion of Brain Gliomas

NCT03262636Phase 1Completed

Two-Part Study to Evaluate the Safety and Efficacy of Image Guided Surgery Using Indocyanine Green for Intramolecular Imaging of Nervous System Tumors Compared to Standard of Care, (TumorGlow)

NCT06322342Phase 2Completed

Phase 2 Ascending Dose Safety and Efficacy Study of RVP-001, a Manganese-based MRI Contrast Agent

NCT05634707Early Phase 1Active Not Recruiting

Evaluation of Fluoxetine and Cytotoxic Lysosomal Stress in Glioma (FLIRT)

NCT02442297Phase 1Active Not RecruitingPrimary

T Cells Expressing HER2-specific Chimeric Antigen Receptors(CAR) for Patients With HER2-Positive CNS Tumors

NCT04074785Early Phase 1Terminated

Abemaciclib w/Bevacizumab in Recurrent GBM Pts w/Loss of CDKN2A/B or Gain or Amplification of CDK4/6

NCT03593330Not ApplicableTerminated

Neurosurgical Transitional Care Programme

NCT02905110Early Phase 1CompletedPrimary

Methotrexate and Etoposide Infusions Into the Fourth Ventricle in Children with Recurrent Posterior Fossa Brain Tumors

NCT04023669Phase 1Completed

Evaluation of LY2606368 Therapy in Combination With Cyclophosphamide or Gemcitabine for Children and Adolescents With Refractory or Recurrent Group 3/Group 4 or SHH Medulloblastoma Brain Tumors

NCT04525014Phase 1TerminatedPrimary

RRx-001 Given With Irinotecan and Temozolomide for Pediatric Patients With Recurrent or Progressive Malignant Solid and Central Nervous System Tumors

NCT03763396Early Phase 1Not Yet RecruitingPrimary

Azoles Targeting Recurrent High Grade Gliomas

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