Key Insights

Highlights

Success Rate

59% trial completion

Clinical Risk Assessment

Based on trial outcomes

High Risk

Score: 85/100

Termination Rate

20.0%

9 terminated out of 45 trials

Success Rate

59.1%

-27.4% vs benchmark

Late-Stage Pipeline

9%

4 trials in Phase 3/4

Results Transparency

31%

4 of 13 completed with results

Key Signals

4 with results59% success

Data Visualizations

Phase Distribution

38Total
Not Applicable (11)
Early P 1 (1)
P 1 (3)
P 2 (19)
P 3 (4)

Trial Status

Completed13
Terminated9
Recruiting8
Not Yet Recruiting6
Unknown5
Withdrawn4

Trial Success Rate

59.1%

Benchmark: 86.5%

Based on 13 completed trials

Clinical Trials (45)

Showing 20 of 20 trials
NCT01445483CompletedPrimary

Neuropsychological Changes in Patients Receiving Radiation Therapy for Brain Metastases

NCT07552233Not ApplicableRecruiting

NK Cell Therapy for Malignant Solid Brain Tumors

NCT07449481Phase 2Not Yet Recruiting

A Phase II Clinical Study of Utidelone and Bevacizumab With or Without Etoposide in Patients With Brain Metastases From Malignant Solid Tumors

NCT06159335Phase 3RecruitingPrimary

18F-FLUC PET/MR in Patients With Brain Mets

NCT05102747Not ApplicableRecruitingPrimary

Stereotactic Radiotherapy in Oligometastatic Brain Disease: a Randomised Phase III Study Comparing Hypofractionated Stereotactic Radiation Therapy (3*10 Gy) to the Historical Single-dose Radiosurgery (1*20 to 25 Gy) With Medico-economic Evaluation.

NCT07355348Not ApplicableRecruiting

Feasibility of a Cognitive Stepped Care Program for Adults With Brain Metastases

NCT07343479Phase 2Not Yet Recruiting

Sacituzumab Tirumotecan Plus Third-Generation TKI With/Without Radiotherapy for EGFR-Mutant NSCLC Brain Metastases

NCT07329634Phase 3Not Yet RecruitingPrimary

Evaluation of Neoadjuvant Stereotactic Radiosurgery (SRS) and Multi-fraction SRS Alone for the Treatment of Large Brain Metastases

NCT06582940Phase 2Recruiting

Elimination of PTV Margins Based on MRI-guided Adaptive Stereotactic Radiotherapy for Non-small Cell Lung Cancer With Brain Metastasis

NCT07011849Phase 2Withdrawn

Study of Lenvatinib Plus Pembrolizumab in IO Refractory mRCC Patients With Brain Metastases

NCT02681549Phase 2Completed

Pembrolizumab Plus Bevacizumab for Treatment of Brain Metastases in Metastatic Melanoma or Non-small Cell Lung Cancer (NSCLC)

NCT01324635Phase 1Terminated

Panobinostat and Stereotactic Radiation Therapy in Treating Patients With Brain Tumors

NCT06852001Not ApplicableNot Yet RecruitingPrimary

Efficacy of the RayerKnife X Stereotactic Radiotherapy System in the Treatment of Brain Metastases

NCT06462079Phase 2Not Yet RecruitingPrimary

Sacituzumab Govitecan Combined With Head Radiotherapy for Her2-negative Breast Cancer Brain Metastases

NCT02621515Phase 2Terminated

Nivo/Ipi Combination Therapy in Symptomatic Brain Metastases

NCT06330870Not ApplicableRecruiting

Brain Metastasis Development Mechanism in BCBM Patients

NCT01894633Phase 2TerminatedPrimary

Study of Whole-brain Irradiation With Chloroquine for Brain Metastases

NCT06210438Phase 2Not Yet Recruiting

SHR-A1921 Combined With Bevacizumab in Triple-negative Breast Cancer With Brain Metastases

NCT03190967Phase 1Terminated

T-DM1 Alone Versus T-DM1 and Metronomic Temozolomide in Secondary Prevention of HER2-Positive Breast Cancer Brain Metastases Following Stereotactic Radiosurgery

NCT01508221Phase 2CompletedPrimary

Evaluation of the Use of Trental and Vitamin E For Prophylaxis of Radiation Necrosis

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