Key Insights

Highlights

Success Rate

50% trial completion

Clinical Risk Assessment

Based on trial outcomes

High Risk

Score: 75/100

Termination Rate

25.0%

3 terminated out of 12 trials

Success Rate

50.0%

-36.5% vs benchmark

Late-Stage Pipeline

0%

0 trials in Phase 3/4

Results Transparency

100%

3 of 3 completed with results

Key Signals

3 with results50% success

Data Visualizations

Phase Distribution

9Total
P 1 (1)
P 2 (8)

Trial Status

Recruiting3
Terminated3
Completed3
Unknown1
Not Yet Recruiting1
Active Not Recruiting1

Trial Success Rate

50.0%

Benchmark: 86.5%

Based on 3 completed trials

Clinical Trials (12)

Showing 12 of 12 trials
NCT05004350Phase 2CompletedPrimary

A Study Evaluating the Combination of Encorafenib and Cetuximab Versus Irinotecan/Cetuximab or Infusional 5-fluorouracil (5-FU)/Folinic Acid (FA)/Irinotecan (FOLFIRI)/Cetuximab in Chinese Patients With BRAF V600E Mutant Metastatic Colorectal Cancer.

NCT05786924Phase 1Recruiting

Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies

NCT07506109Phase 2Not Yet RecruitingPrimary

A Phase II Study of Sintilimab Combined With Ipilimumab N01, Cetuximab and Dabrafenib in Patients With Microsatellite-Stable, BRAF V600E-Mutated Metastatic Colorectal Cancer

NCT03042221Recruiting

Early Rebiopsy to Identify Biomarkers of Tumor Cell Survival Following EGFR, ALK, ROS1 or BRAF TKI Therapy

NCT04526782Phase 2Active Not Recruiting

ENCOrafenib With Binimetinib in bRAF NSCLC

NCT05510895Phase 2Completed

Neoadjuvant Encorafenib, Binimetinib and Cetuximab for Patients With BRAF V600E Mutated/pMMR Localized Colorectal Cancer

NCT05304546Phase 2Completed

Overcoming Primary Resistance to Immunotherapy in Metastatic Melanoma

NCT03973918Phase 2Terminated

Study of Binimetinib With Encorafenib in Adults With Recurrent BRAF V600-Mutated HGG

NCT04534283Phase 2Terminated

A Basket Trial of an ERK1/2 Inhibitor (LY3214996) in Combination With Abemaciclib.

NCT06539702Recruiting

Preoperative Hemogram Parameters and BRAF Molecular Test Detected by Bethesda 3 Cytology.

NCT03593993Terminated

A Biospecimen Collection Study in BRAF-V600E Mutated Recurrent Gliomas

NCT03543306Phase 2Unknown

Dabrafenib and Trametinib in Patients With Non-small Cell Lung Cancer Harboring V600E BRAF Mutation

Showing all 12 trials

Research Network

Activity Timeline