Bipolar Depression
190
26
32
112
Key Insights
Highlights
Success Rate
87% trial completion (above average)
Published Results
58 trials with published results (31%)
Research Maturity
112 completed trials (59% of total)
Clinical Risk Assessment
Based on trial outcomes
Low Risk
Score: 17/100
8.9%
17 terminated out of 190 trials
86.8%
+0.3% vs benchmark
33%
63 trials in Phase 3/4
52%
58 of 112 completed with results
Key Signals
Data Visualizations
Phase Distribution
Trial Status
Trial Success Rate
Benchmark: 86.5%
Based on 112 completed trials
Clinical Trials (190)
Multicenter Study of Lumateperone for the Treatment of Bipolar Depression in Pediatric Patients
EEG Microstate and Neuroinflammatory Biomarkers in Older Age Patients With Major Depressive Disorder Receiving ECT
A Pilot Study Investigating the Efficacy of Minocycline and N-Acetyl Cysteine for Bipolar Depression
Lithium Effects on the Brain's Functional and Structural Connectome in the Treatment of Bipolar Disorder
Ketamine Associated ACC GABA and Glutamate Change and Depression Remission:
Xenon Inhalation Therapy for Major Depressive Disorder and Bipolar Disorder
RNA Editing as a Biomarker of Antidepressant Response in Unipolar and Bipolar Depression (EDIT-ANDRE)
A Randomized Study of Azetukalner Versus Placebo in Depressive Episodes Associated With Bipolar I or II Disorder (Bipolar Depression)
An Open-label Study of Azetukalner in Bipolar I or II Depression (X-CEED-OLE)
Efficacy and Safety Assessment of Temporal Interference Stimulation to Improve Bipolar Depression
Task-State-Based Temporal Interference Stimulation (TI) to Improve Depression in Patients With Bipolar Disorder
SYNCED - SYNChronized Eating in Bipolar Depression Study
Focused Ultrasound Amygdala Neuromodulation
Electro-Magnetic Convulsive Therapies for Depression: a Non-inferiority Study
Dopamine D3 Receptor Occupancy in Bipolar Depression
Low Field Magnetic Stimulation: Imaging Biomarkers in Geriatric Bipolar Depression
Theta-Burst Stimulation for Bipolar Depression
Empagliflozin Adjunctive Therapy in Bipolar Depression
Ketamine for Treatment-Resistant Bipolar Disorder
Adjunctive Bright Light Therapy in Patients With Bipolar Depression and Eveningness