Key Insights

Highlights

Success Rate

87% trial completion (above average)

Published Results

58 trials with published results (31%)

Research Maturity

110 completed trials (58% of total)

Clinical Risk Assessment

Based on trial outcomes

Low Risk

Score: 17/100

Termination Rate

8.9%

17 terminated out of 190 trials

Success Rate

86.6%

+0.1% vs benchmark

Late-Stage Pipeline

33%

63 trials in Phase 3/4

Results Transparency

53%

58 of 110 completed with results

Key Signals

58 with results87% success17 terminated

Data Visualizations

Phase Distribution

174Total
Not Applicable (57)
Early P 1 (5)
P 1 (12)
P 2 (37)
P 3 (36)
P 4 (27)

Trial Status

Completed110
Recruiting25
Unknown18
Terminated17
Withdrawn7
Active Not Recruiting6

Trial Success Rate

86.6%

Benchmark: 86.5%

Based on 110 completed trials

Clinical Trials (190)

Showing 20 of 20 trials
NCT05060549Phase 4WithdrawnPrimary

Dopamine D3 Receptor Occupancy in Bipolar Depression

NCT07172516Phase 3Recruiting

A Randomized Study of Azetukalner Versus Placebo in Depressive Episodes Associated With Bipolar I or II Disorder (Bipolar Depression)

NCT03484494Not ApplicableActive Not Recruiting

Low Field Magnetic Stimulation: Imaging Biomarkers in Geriatric Bipolar Depression

NCT06370988Not ApplicableRecruitingPrimary

Theta-Burst Stimulation for Bipolar Depression

NCT07472920Not ApplicableNot Yet Recruiting

Empagliflozin Adjunctive Therapy in Bipolar Depression

NCT07217860Phase 3Enrolling By InvitationPrimary

An Open-label Study of Azetukalner in Bipolar I or II Depression (X-CEED-OLE)

NCT05357313Not ApplicableActive Not RecruitingPrimary

Adjunctive Bright Light Therapy in Patients With Bipolar Depression and Eveningness

NCT05004896Phase 2Completed

Ketamine for Treatment-Resistant Bipolar Disorder

NCT05339074Phase 2Completed

Maintenance Ketamine Infusions for Treatment-Resistant Bipolar Depression

NCT04480918Recruiting

University of Iowa Interventional Psychiatry Service Patient Registry

NCT06488573Not ApplicableRecruitingPrimary

PROgram To Enhance Cardiovascular Risk Trough an Intervention of Nutrition in Bipolar Disorder

NCT06524505Not ApplicableRecruitingPrimary

Efficacy, Tolerability, and Cognitive Effects of Deep Transcranial Magnetic Stimulation for Bipolar Depression

NCT03336918Active Not Recruiting

Lithium Effects on the Brain's Functional and Structural Connectome in the Treatment of Bipolar Disorder

NCT07266545Phase 4Recruiting

RNA Editing as a Biomarker of Antidepressant Response in Unipolar and Bipolar Depression (EDIT-ANDRE)

NCT05340686Not ApplicableSuspended

Braining- Aerobic Physical Activity as Add on Treatment in Bipolar Depression

NCT06599099Not ApplicableRecruitingPrimary

Deep Brain Stimulation of Treatment-Resistant Bipolar Depression

NCT07121894Not ApplicableRecruitingPrimary

Ketogenic Intervention for Bipolar Depression

NCT05603104Phase 3Recruiting

Intensified Pharmacological Treatment for Schizophrenia, Major Depressive Disorder and Bipolar Depression After a First-time Treatment Failure

NCT07246044Not ApplicableRecruiting

HD-tDCS for Adolescent Bipolar Depression Targeting S1

NCT06620042Phase 2CompletedPrimary

FMRI of Patients Receiving IV Ketamine for Treatment Resistant Bipolar Depression

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