Key Insights

Highlights

Success Rate

92% trial completion (above average)

Clinical Risk Assessment

Based on trial outcomes

Moderate Risk

Score: 50/100

Termination Rate

3.6%

1 terminated out of 28 trials

Success Rate

91.7%

+5.2% vs benchmark

Late-Stage Pipeline

4%

1 trials in Phase 3/4

Results Transparency

18%

2 of 11 completed with results

Key Signals

2 with results92% success

Data Visualizations

Phase Distribution

9Total
Not Applicable (7)
P 2 (1)
P 3 (1)

Trial Status

Completed11
Recruiting5
Unknown5
Active Not Recruiting4
Terminated1
Enrolling By Invitation1

Trial Success Rate

91.7%

Benchmark: 86.5%

Based on 11 completed trials

Clinical Trials (28)

Showing 20 of 20 trials
NCT03635424Not ApplicableActive Not RecruitingPrimary

Medtronic Transcatheter Aortic Valve Replacement (TAVR) Low Risk Bicuspid Study

NCT01026571Active Not RecruitingPrimary

Identification of Genetic Causes of Bicuspid Aortic Valve Disease

NCT03440697Active Not Recruiting

Pathogenetic Basis of Aortopathy and Aortic Valve Disease

NCT05711693Not ApplicableCompleted

Measurement of Heart-carotid Pulse Wave Velocity (hcPWV) by Laser Doppler Vibrometry (LDV)

NCT03474159Not ApplicableCompletedPrimary

Evaluation of Aortic Stiffness as a Prognostic Indicator of Aortic Dilatation in Patients With Bicuspid Aortic Valve by Multimodal Imaging

NCT06817148Not ApplicableRecruiting

Bicuspid Aortic Valve Replacement: Evaluation of Transcatheter Versus Surgery-Pilot Trial

NCT05739253Recruiting

Changes of Ascending Aortic Diameter in Patients Undergoing Transcatheter Aortic Valve Replacement

NCT04817735Not ApplicableCompletedPrimary

The CASPER Registry

NCT01756222RecruitingPrimary

Bicuspid Aortic Valve (BAV) Registry

NCT05389865Active Not Recruiting

Proximal Aortopathy in Scotland - Epidemiology and Surgical Outcomes

NCT06212050Enrolling By Invitation

Feasibility, Safety, and Effectiveness of the ACURATE neo2 Transcatheter Heart Valve for Severe Bicuspid Aortic Stenosis

NCT06375590Not Yet RecruitingPrimary

NavIIcusp: Bicuspid Aortic Valve Stenosis With Navitor Platform International Experience

NCT06153407RecruitingPrimary

Genetic Test Based Risk Prediction of Early Calcific Aortic Valve Disease in Patients With Bicuspid Aortic Valve

NCT04083118CompletedPrimary

Assessment of Risk in Thoracic Aortopathy Using 18F-Sodium Fluoride

NCT05836363CompletedPrimary

Fate at Long-term of Mild to Moderate Bicuspid Aortic Valve Disease Left Untreated at the Time of Supracoronary Ascending Aorta Replacement

NCT05818722UnknownPrimary

A Multicentre Retrospective Study on Bicuspid Aortic Valve

NCT05708118UnknownPrimary

Progression of Ascending Aorta Diameters in Bicuspid Aortic Valve After Transcatheter or Surgical Replacement.

NCT01823432CompletedPrimary

Genetic Risks for Bicuspid Aortic Valve Disease

NCT02679261Phase 3CompletedPrimary

Evaluating the Effectiveness of Atorvastatin on the Progression of Aortic Dilatation and Valvular Degeneration in Patients With Bicuspid Aortic Valve

NCT03836521RecruitingPrimary

Bicuspid Aortic Valve Stenosis Transcatheter Aortic Valve Replacement Registry

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Research Network

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