Key Insights

Highlights

Success Rate

78% trial completion

Published Results

11 trials with published results (21%)

Clinical Risk Assessment

Based on trial outcomes

High Risk

Score: 72/100

Termination Rate

15.4%

8 terminated out of 52 trials

Success Rate

78.4%

-8.1% vs benchmark

Late-Stage Pipeline

4%

2 trials in Phase 3/4

Results Transparency

38%

11 of 29 completed with results

Key Signals

11 with results78% success

Data Visualizations

Phase Distribution

46Total
Not Applicable (2)
Early P 1 (1)
P 1 (30)
P 2 (11)
P 3 (1)
P 4 (1)

Trial Status

Completed29
Terminated8
Recruiting5
Withdrawn3
Active Not Recruiting3
Unknown3

Trial Success Rate

78.4%

Benchmark: 86.5%

Based on 29 completed trials

Clinical Trials (52)

Showing 20 of 20 trials
NCT03975829Phase 4Recruiting

Pediatric Long-Term Follow-up and Rollover Study

NCT06108206Active Not Recruiting

Adaptive Radiotherapy and MRIs Based on Patients With Newly Diagnosed High-Grade Glioma

NCT05934630Terminated

Testing Cerebrospinal Fluid for Cell-free Tumor DNA in Children, Adolescents, and Young Adults With Brain Tumors

NCT05698524Phase 1Recruiting

A Study of Temodar With Abexinostat (PCI-24781) for Patients With Recurrent Glioma

NCT07468136Phase 1Not Yet RecruitingPrimary

Retifanlimab With or Without Difluoromethylornithine for the Treatment of Progressive High Grade Gliomas

NCT04978727Phase 1Active Not Recruiting

A Pilot Study of SurVaxM in Children Progressive or Relapsed Medulloblastoma, High Grade Glioma, Ependymoma and Newly Diagnosed Diffuse Intrinsic Pontine Glioma

NCT04623931Phase 2Recruiting

Chemotherapy and Radiation Therapy for the Treatment of IDH Wildtype Gliomas or Non-histological (Molecular) Glioblastomas

NCT04295759Phase 1Completed

INCB7839 in Treating Children With Recurrent/Progressive High-Grade Gliomas

NCT04541082Phase 1Recruiting

Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms

NCT01849952Terminated

Evaluating the Expression Levels of MicroRNA-10b in Patients With Gliomas

NCT04135807Early Phase 1Recruiting

Implantable Microdevice In Primary Brain Tumors

NCT03180502Phase 2Active Not Recruiting

Proton Beam or Intensity-Modulated Radiation Therapy in Preserving Brain Function in Patients With IDH Mutant Grade II or III Glioma

NCT02101905Phase 1Completed

Lapatinib Ditosylate Before Surgery in Treating Patients With Recurrent High-Grade Glioma

NCT03434262Phase 1Completed

SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors

NCT03043391Phase 1Completed

Phase 1b Study PVSRIPO for Recurrent Malignant Glioma in Children

NCT02684058Phase 2Completed

Study of Efficacy and Safety of Dabrafenib in Combination With Trametinib in Pediatric Patients With BRAF V600 Mutation Positive LGG or Relapsed or Refractory HGG Tumors

NCT02168270Phase 1Terminated

Temozolomide and Ascorbic Acid in Treating Patients With Recurrent High-Grade Glioma

NCT03971734Phase 1Terminated

Determining Dose of Regadenoson Most Likely to Transiently Alter the Integrity of the Blood-Brain Barrier in Patients With High Grade Gliomas

NCT02238496Phase 1Completed

Perifosine and Torisel (Temsirolimus) for Recurrent/Progressive Malignant Gliomas

NCT01721577Phase 1Terminated

Phase I/II Trial of AXL1717 in the Treatment of Recurrent Malignant Astrocytomas

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