Key Insights

Highlights

Success Rate

73% trial completion

Published Results

29 trials with published results (24%)

Research Maturity

63 completed trials (52% of total)

Clinical Risk Assessment

Based on trial outcomes

High Risk

Score: 59/100

Termination Rate

18.9%

23 terminated out of 122 trials

Success Rate

73.3%

-13.3% vs benchmark

Late-Stage Pipeline

7%

9 trials in Phase 3/4

Results Transparency

46%

29 of 63 completed with results

Key Signals

29 with results73% success23 terminated

Data Visualizations

Phase Distribution

105Total
Not Applicable (4)
Early P 1 (2)
P 1 (60)
P 2 (30)
P 3 (8)
P 4 (1)

Trial Status

Completed63
Terminated23
Recruiting13
Unknown9
Withdrawn6
Active Not Recruiting6

Trial Success Rate

73.3%

Benchmark: 86.5%

Based on 63 completed trials

Clinical Trials (122)

Showing 20 of 20 trials
NCT03975829Phase 4Recruiting

Pediatric Long-Term Follow-up and Rollover Study

NCT03919071Phase 2Active Not RecruitingPrimary

Dabrafenib Combined With Trametinib After Radiation Therapy in Treating Patients With Newly-Diagnosed High-Grade Glioma

NCT03581292Phase 2Active Not RecruitingPrimary

Veliparib, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed Malignant Glioma Without H3 K27M or BRAFV600 Mutations

NCT06108206Active Not Recruiting

Adaptive Radiotherapy and MRIs Based on Patients With Newly Diagnosed High-Grade Glioma

NCT05934630TerminatedPrimary

Testing Cerebrospinal Fluid for Cell-free Tumor DNA in Children, Adolescents, and Young Adults With Brain Tumors

NCT05843253Phase 2Recruiting

Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant

NCT05698524Phase 1Recruiting

A Study of Temodar With Abexinostat (PCI-24781) for Patients With Recurrent Glioma

NCT02800486Phase 2Recruiting

Super Selective Intra-arterial Repeated Infusion of Cetuximab (Erbitux) With Reirradiation for Treatment of Relapsed/Refractory GBM, AA, and AOA

NCT05839379Recruiting

Targeted Pediatric High-Grade Glioma Therapy

NCT03603405Phase 1Recruiting

HSV-tk and XRT and Chemotherapy for Newly Diagnosed GBM

NCT06333899Early Phase 1Recruiting

Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion

NCT04978727Phase 1Active Not Recruiting

A Pilot Study of SurVaxM in Children Progressive or Relapsed Medulloblastoma, High Grade Glioma, Ependymoma and Newly Diagnosed Diffuse Intrinsic Pontine Glioma

NCT07448480Active Not Recruiting

Comprehensive Analysis of Chemotherapy and Targeted Therapy Outcomes in Recurrent Malignant Gliomas

NCT05084430Phase 1Recruiting

Study of Pembrolizumab and M032 (NSC 733972)

NCT04295759Phase 1Completed

INCB7839 in Treating Children With Recurrent/Progressive High-Grade Gliomas

NCT04541082Phase 1Recruiting

Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms

NCT05956821Phase 1Recruiting

Treatment of Relapsed/Refractory Intracranial Glioma in Patients Under 22 Years of Age

NCT01849952Terminated

Evaluating the Expression Levels of MicroRNA-10b in Patients With Gliomas

NCT03180502Phase 2Active Not RecruitingPrimary

Proton Beam or Intensity-Modulated Radiation Therapy in Preserving Brain Function in Patients With IDH Mutant Grade II or III Glioma

NCT04780009Recruiting

Loupe-Based Intraoperative Fluorescence Imaging

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