Key Insights

Highlights

Success Rate

73% trial completion

Published Results

39 trials with published results (49%)

Research Maturity

54 completed trials (68% of total)

Clinical Risk Assessment

Based on trial outcomes

High Risk

Score: 62/100

Termination Rate

25.0%

20 terminated out of 80 trials

Success Rate

73.0%

-13.5% vs benchmark

Late-Stage Pipeline

0%

0 trials in Phase 3/4

Results Transparency

72%

39 of 54 completed with results

Key Signals

39 with results73% success20 terminated

Data Visualizations

Phase Distribution

78Total
Not Applicable (7)
Early P 1 (2)
P 1 (43)
P 2 (26)

Trial Status

Completed54
Terminated20
Recruiting2
Withdrawn2
Active Not Recruiting2

Trial Success Rate

73.0%

Benchmark: 86.5%

Based on 54 completed trials

Clinical Trials (80)

Showing 20 of 20 trials
NCT00268385Phase 1Active Not Recruiting

Vorinostat and Temozolomide in Treating Patients With Malignant Gliomas

NCT02142803Phase 1Active Not RecruitingPrimary

TORC1/2 Inhibitor MLN0128 and Bevacizumab in Treating Patients With Recurrent Glioblastoma or Advanced Solid Tumors

NCT04573140Phase 1RecruitingPrimary

A Study of RNA-lipid Particle (RNA-LP) Vaccines for Newly Diagnosed Pediatric High-Grade Gliomas (pHGG) and Adult Glioblastoma (GBM)

NCT01165632Early Phase 1Completed

Fluorine F 18 Fluorodopa-Labeled PET Scan in Planning Surgery and Radiation Therapy in Treating Patients With Newly Diagnosed High- or Low-Grade Malignant Glioma

NCT02186509Phase 1Completed

Alisertib and Fractionated Stereotactic Radiosurgery in Treating Patients With Recurrent High Grade Gliomas

NCT01894061Phase 2Completed

NovoTTF-100A With Bevacizumab (Avastin) in Patients With Recurrent Glioblastoma

NCT04143425CompletedPrimary

Response Prediction for Anti-angiogenic Treatment in Recurrent Glioblastoma

NCT02613988Not ApplicableRecruitingPrimary

Advanced MR Imaging as Predictor of Treatment Response in Newly Diagnosed Glioblastomas

NCT02060890CompletedPrimary

Molecular Profiling in Guiding Individualized Treatment Plan in Adults With Recurrent/Progressive Glioblastoma

NCT02530502Phase 1TerminatedPrimary

Radiation Therapy With Temozolomide and Pembrolizumab in Treating Patients With Newly Diagnosed Glioblastoma

NCT00662506Phase 1Completed

Cediranib, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma

NCT01730950Phase 2Completed

Bevacizumab With or Without Radiation Therapy in Treating Patients With Recurrent Glioblastoma

NCT00731731Phase 1Completed

Vorinostat, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme

NCT01062425Phase 2CompletedPrimary

Temozolomide and Radiation Therapy With or Without Cediranib Maleate in Treating Patients With Newly Diagnosed Glioblastoma

NCT02015819Phase 1Completed

Genetically Modified Neural Stem Cells, Flucytosine, and Leucovorin for Treating Patients With Recurrent High-Grade Gliomas

NCT01051557Phase 1Completed

Temsirolimus and Perifosine in Treating Patients With Recurrent or Progressive Malignant Glioma

NCT00052208Phase 1Completed

Gefitinib and Radiation Therapy in Treating Patients With Glioblastoma Multiforme

NCT01478321Phase 2Terminated

Efficacy of Hypofractionated XRT w/Bev. + Temozolomide for Recurrent Gliomas

NCT01806675Phase 1Completed

18F-FPPRGD2 PET/CT or PET/MRI in Predicting Early Response in Patients With Cancer Receiving Anti-Angiogenesis Therapy

NCT02364206Phase 1CompletedPrimary

Study of LY2228820 With Radiotherapy Plus Concomitant TMZ in the Treatment of Newly Diagnosed Glioblastoma

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Research Network

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