Key Insights

Highlights

Success Rate

80% trial completion

Clinical Risk Assessment

Based on trial outcomes

High Risk

Score: 62/100

Termination Rate

12.5%

3 terminated out of 24 trials

Success Rate

80.0%

-6.5% vs benchmark

Late-Stage Pipeline

13%

3 trials in Phase 3/4

Results Transparency

33%

4 of 12 completed with results

Key Signals

4 with results80% success

Data Visualizations

Phase Distribution

19Total
Not Applicable (6)
P 1 (2)
P 2 (8)
P 3 (3)

Trial Status

Completed12
Recruiting3
Not Yet Recruiting3
Terminated3
Unknown2
Withdrawn1

Trial Success Rate

80.0%

Benchmark: 86.5%

Based on 12 completed trials

Clinical Trials (24)

Showing 20 of 20 trials
NCT06880679Not ApplicableRecruitingPrimary

Ultrasound Acute Chest Syndrome Sickle Cell Disease

NCT07246265Not ApplicableRecruiting

Morphine Clearance and Glomerular Filtration in Sickle Cell Patients in Crisis in Intensive Care

NCT04170348Phase 2Completed

Daily Vitamin D for Sickle-cell Respiratory Complications

NCT06698120Not ApplicableNot Yet RecruitingPrimary

Awake Prone Positioning for Severe Acute Chest Syndrome

NCT07037706Completed

Use of Macrolides in Acute Chest Syndrome: A Multicenter Retrospective Study

NCT05640271Phase 2Recruiting

Tocilizumab for Acute Chest Syndrome

NCT03919266Not ApplicableCompletedPrimary

Combined Use of a Respiratory Broad Panel Multiplex PCR and Procalcitonin to Reduce Antibiotics Exposure in Hospitalized Sickle-cell Adults With Acute Chest Syndrome.

NCT06818266Phase 3Not Yet Recruiting

Efficacy and Safety of Tocilizumab for Acute Chest Syndrome Treatment in Patients With Sickle Cell Disease

NCT01443728Phase 2Completed

Vitamin D for Sickle-cell Respiratory Complications

NCT02580773Phase 3Completed

Therapeutic Anticoagulation Strategy for Acute Chest Syndrome

NCT06214845Not ApplicableNot Yet RecruitingPrimary

Early-goal Directed Automated Red Blood Cell Exchange for Acute Chest Syndrome in Sickle Cell Disease

NCT03805581Phase 2Completed

Defibrotide in Sickle Cell Disease-Related Acute Chest Syndrome

NCT03032055Unknown

Validation of a Predictive Score of Acute Chest Syndrome

NCT03820466Phase 3TerminatedPrimary

Effect of Platelet Inhibition and / or Lipid Lowering in Non-ACS-patients With Positive Troponin

NCT03498105UnknownPrimary

Utility of the Cardiac Electrical BiomarkerDisease

NCT02098993Phase 2TerminatedPrimary

Feasibility Study of Unfractionated Heparin in Acute Chest Syndrome

NCT01589926Not ApplicableTerminated

Bi-Level Positive Airway Ventilation for Acute Chest Syndrome

NCT03250585Completed

sPLA2 in EBC During Acute Chest Syndrome

NCT02630394Phase 1Withdrawn

A Pilot Study of Azithromycin Prophylaxis for Acute Chest Syndrome in Sickle Cell Disease

NCT02187445Phase 1Completed

Inhaled Corticosteroid Use to Prevent Acute Chest Syndrome Recurrence in Children Between 1 and 4 With Sickle Cell Disease: a Feasibility Trial

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